OCTOBER 2024 NEWSLETTER
The newsletter of the Feinberg School of Medicine Research Office
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Improving the Science and Treatment of Glioblastoma |
| The average length of survival for glioblastoma has failed to improve since it was first identified in scientific literature nearly 100 years ago. Despite this, scientists at Feinberg remain steadfast in their commitment to improving the understanding and treatment of glioblastoma through rigorous research initiatives and clinical trials. |
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Gordon Delivers Nemmers Prize Keynote Lecture |
| Jeffrey Gordon, MD, a distinguished university professor at Washington University in St. Louis often referred to as the “father of microbiome research,” and recipient of the 2024 Mechthild Esser Nemmers Prize in Medical Science, visited Feinberg’s campus to deliver the keynote lecture on September 30. |
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Northwestern Establishes New Center for Ataxia Research and Treatment |
| Northwestern has established the Denning Ataxia Center, a multidisciplinary hub dedicated to improving the understanding of ataxia through integrating leading-edge research with patient-centered clinical care, with the goal of unraveling the complexities of the condition and developing improved treatments. |
Faculty ProfileStudying the Underlying Neural Mechanisms of Language ImpairmentBorna Bonakdarpour, MD, is an associate professor of Neurology in the Division of Behavioral Neurology. His laboratory uses multimodal neuroimaging to study the underlying neural mechanisms of language impairment (aphasia) and impairment in other areas of cognition and use this information to develop and evaluate effective treatments for aphasia. |
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Staff ProfileCollaborating to Enhance Departmental ResearchKashmeen Raza is associate department administrator for the Department of Surgery. Currently, Raza works alongside several leaders within the Department of Surgery to enhance research infrastructure and empower high-quality research. |
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Student ProfileDesigning Aggregation-Resistant ProteinsCydney Martell is a fifth-year PhD candidate in the Driskill Graduate Program in Life Sciences (DGP). In the laboratory of Gabriel Rocklin, PhD, assistant professor of Pharmacology, Martell examines factors that impact the stability of proteins to optimize their design to treat a variety of diseases. |
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Campus Events |
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Research in the NewsHealthDay, October 8 NPR, September 30 Crain's Chicago Business, September 17 |
NUCATS CornerConnecting You to the Resources You NeedThe NUCATS Institute’s Center for Education and Career Development (CECD) trains the entire translational research workforce through more than a dozen programs, allowing early career faculty, postdoctoral fellows, scholars, trainees and clinical research professionals to advance Northwestern's research enterprise. CECD connects you to the resources you need. |
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Sponsored Research4D virtual Catheter (4D vCath) for multi-factorial hemodynamics in pulmonary hypertension
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Sponsored ResearchThe immunosuppressive function of Checkpoint kinase 2 in gliomas
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Breakthroughs PodcastUnderstanding Gut Microbiome Science with Jeffrey Gordon, MDJeffrey Gordon, MD, often called “the father of microbiome research,” is the 2024 recipient of the Nemmers Prize. In this episode, Gordon discusses the impacts of his long career in gut microbiome research, which has profoundly transformed our understanding of human health. Specifically, he shares the evolution of groundbreaking approaches to treating malnutrition and childhood undernutrition with microbiota-targeted therapies. |
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New FacultyLili Zhao, PhD, recently joined Feinberg in August 2024 as professor of Biostatistics and associate director of Biostatistics in the Quantitative Data Sciences Core (QDSC) at the Robert H. Lurie Comprehensive Cancer Center. Her statistical research encompasses a wide range of areas, including the analysis of electronic health record data, survival data analysis, causal inference, Bayesian methods and machine learning techniques such as federated learning. Zhao is dedicated to developing, translating and advancing innovative statistical methodologies for population health and biomedical research. She has served as a co-investigator on numerous NIH-funded studies and is currently the principal investigator on an R01 grant focused on developing efficient statistical approaches to study adverse events following vaccinations. Additionally, she is a multi-principal investigator working on developing machine learning models for dynamic prediction of survival in patients with COPD. |
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Galter LibraryPublishing Insights: Open Access (OA) Week 2024International Open Access week is October 21-27, and the theme is Community over Commercialization, encouraging us all to “prioritize approaches to open scholarship that serve the best interests of the public and the academic community.” |
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High Impact ResearchSasmita AO, Depp C, Nazarenko T, Sun T, Siems SB, Ong EC, Nkeh YB, Böhler C, Yu X, Bues B, Evangelista L, Mao S, Morgado B, Wu Z, Ruhwedel T, Subramanian S, Börensen F, Overhoff K, Spieth L, Berghoff SA, Sadleir KR, Vassar R, Eggert S, Goebbels S, Saito T, Saido T, Saher G, Möbius W, Castelo-Branco G, Klafki HW, Wirths O, Wiltfang J, Jäkel S, Yan R, Nave KA. Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice. Nature Neuroscience. September 2024; 27(9):1668-1674. Schubert MC, Soyka SJ, Tamimi A, Maus E, Schroers J, Wißmann N, Reyhan E, Tetzlaff SK, Yang Y, Denninger R, Peretzke R, Beretta C, Drumm M, Heuer A, Buchert V, Steffens A, Walshon J, McCortney K, Heiland S, Bendszus M, Neher P, Golebiewska A, Wick W, Winkler F, Breckwoldt MO, Kreshuk A, Kuner T, Horbinski C, Kurz FT, Prevedel R, Venkataramani V. Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis. Nature Communications. September 2024; 15(1):7383-7383. Siniscalco ER, Williams A, Eisenbarth SC. All roads lead to IgA: Mapping the many pathways of IgA induction in the gut. Immunological Reviews. September 2024; 326(1):66-82. Willim J, Woike D, Greene D, Das S, Pfeifer K, Yuan W, Lindsey A, Itani O, Böhme AL, Tibbe D, Hönck HH, Hassani Nia F, , Zech M, Brunet T, Faivre L, Sorlin A, Vitobello A, Smol T, Colson C, Baranano K, Schatz K, Bayat A, Schoch K, Spillmann R, Davis EE, Conboy E, Vetrini F, Platzer K, Neuser S, Gburek-Augustat J, Grace AN, Mitchell B, Stegmann A, Sinnema M, Meeks N, Saunders C, Cadieux-Dion M, Hoyer J, Van-Gils J, de Sainte-Agathe JM, Thompson ML, Bebin EM, Weisz-Hubshman M, Tabet AC, Verloes A, Levy J, Latypova X, Harder S, Silverman GA, Pak SC, Schedl T, Freson K, Mumford A, Turro E, Schlein C, Shashi V, Kreienkamp HJ. Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors. Nature Communications. September 2024; 15(1):7909-7909. |
Featured CoreDevelopmental Therapeutics CoreUnder the umbrella of Chemistry of Life Processes Institute (CLP), the Developmental Therapeutics Core (DTC) provides an operational laboratory that supports translational projects and fulfills the needs of the research community for exploratory drug development work. The aim is to rapidly and efficiently advance novel therapeutic interventions from basic research to the clinic. Services Offered
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NIH NewsNIH is pleased to announced the new NIH Grants and Funding website has launched. Designed with the needs of the extramural research community in mind, the new site is intended to enhance user journey through the NIH grants process with a modernized interface and powerful features to make finding critical information easier than ever. A key change involves a redesign of the NIH Guide for Grants and Contracts and related funding information. The new tools reduce reliance on activity codes and other NIH jargon to help users explore opportunities for funding in a more intuitive way. NIH Grants Process Primer: Application to Award (Two-Part Virtual Event – November 13 & 14) Understanding the structure of NIH, the application process, policies, tools and systems, and knowing where to find valuable resources are key components to create a strong NIH application. On November 13 and 14, NIH is hosting a two-part event that will provide participants with the basics to help you in your role working with the NIH grants process from application preparation to award. If you are a grant administrator or investigator with limited knowledge of the grants process, and eager to start building a better foundation in your role of working with the NIH, register for this two-part virtual event today. |
Funding OpportunitiesAIDS-Science Track Award for Research Transition (R03 Clinical Trial Optional)
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