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AUGUST 2023 NEWSLETTER
The newsletter of the Feinberg School of Medicine Research Office
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Advancing Our Understanding Behind the Mechanisms of Pain
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Today, more than 50 million adults in the U.S. suffer from chronic pain — pain lasting longer than three months — and is the most common reason why people seek medical attention, according to the Centers for Disease Control and Prevention (CDC).
However, recent breakthroughs made by investigators at Northwestern’s Center for Translational Pain Research are moving the field forward and suggest that the brain’s emotional circuity plays a causal role in chronic pain. Read the Feature
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Faculty Profile
Improving the Diagnosis and Treatment Related to Maternal-Child Health Outcomes
Jeffery Goldstein, MD, PhD, is an assistant professor of Pathology in the Divisions of Perinatal Pathology and Autopsy. For his research and clinical practice, he employs machine learning and bioinformatics to improve the health of pregnant women and their children, primarily through improved diagnosis and fundamental understanding of the placenta.
Read more about Goldstein's research
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Translating Insights from Datasets to Improve Health
Emily Stroup is a fifth-year PhD candidate in the Driskill Graduate Program. In the lab of Zhe Ji, PhD, assistant professor of Pharmacology and McCormick School of Engineering, Stroup combines her data and computational skills with medicine to develop deep learning models to better understand polyadenylation.
Read more about Emily's research
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Thu Aug 08
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Online - 12:00 PM - 1:00 PM
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Fri Aug 09
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Chicago - 12:00 PM - 1:00 PM
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Fri Aug 16
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No Location - 12:00 PM - 1:00 PM
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Wed Aug 21
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Online - 12:00 PM - 1:00 PM
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NUCATS Regulatory Team Provides Comprehensive Study Team Support 
The Regulatory Unit of the Center for Clinical Research (CCR) can assist investigators with meeting essential regulatory activities and provides training and general support to Feinberg research staff. Services include:
- New IRB submission of protocols and amendments
- Preparation and negotiation of informed consent documents
- Assistance with the completion of required documentation and for monitor visits
- Oversight of regulatory binders (physical, E-Regulatory Files, and Complion system binders)
Please visit our new resource page, which includes newly added Regulatory Support Guidelines, for additional information.
Learn more about NUCATS
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Predicting Which Cancer Cells May Become Drug-Resistant with Yogesh Goyal, PhD
Treating cancer has become increasingly difficult as cells develop resistance. Northwestern investigators have sought to address this issue on the cellular level through the development of a novel FateMap tool used to predict the future behavior of cancer cells before they are exposed to cancer-fighting drugs.
In this episode, Yogesh Goyal, PhD, discusses his latest research, published in Nature, and how his lab is addressing complex problems through an interdisciplinary approach.
Listen to the podcast episode
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New Faculty
Joshua J. Ziarek, PhD, joined Feinberg on July 1 as associate professor of Pharmacology. His research interests are in the characterization of biomolecular interactions, the molecular mechanisms of allostery and the rational design of molecular therapeutics and tools with a long-standing interest in G protein-coupled receptors (GPCRs). Previously, Ziarek was assistant professor of Cellular and Molecular Biology at Indiana University. He did his postdoctoral training at Harvard Medical School and earned his PhD from the Medical College of Wisconsin.
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Galter Library
The Power of Open Science
The federal government defines open science as “the principle and practice of making research products and processes available to all, while respecting diverse cultures, maintaining security and privacy, and fostering collaborations, reproducibility, and equity.”
We’ve worked to support this area of need at Galter with resources, training, and services to support the Feinberg community. Highlights include the Prism Repository, classes on data management, and Galter Guides on the NIH Public Access Policy and NIH Data Management Plans.
Read the Full Story
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High Impact Research
Brastianos PK, Twohy E, Geyer S, Gerstner ER, Kaufmann TJ, Tabrizi S, Kabat B, Thierauf J, Ruff MW, Bota DA, Reardon DA, Cohen AL, De La Fuente MI, Lesser GJ, Campian J, Agarwalla PK, Kumthekar P, Mann B, Vora S, Knopp M, Iafrate AJ, Curry WT, Jr., Cahill DP, Shih HA, Brown PD, Santagata S, Barker FG, 2nd, Galanis E. BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas. New England Journal of Medicine. 2023;389(2):118-126.
Buyukcelebi K, Chen X, Abdula F, Elkafas H, Duval AJ, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Bulun SE, Wei JJ, Yue F, Adli M. Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization. Nature Communications. 2023;14(1):4057.
Cameron NA, Yee LM, Dolan BM, O'Brien MJ, Greenland P, Khan SS. Trends in Cardiovascular Health Counseling Among Postpartum Individuals. JAMA. 2023;330(4):359-367.
Chen Z, Lin Z, Obaid SN, Rytkin E, George SA, Bach C, Madrid M, Liu M, LaPiano J, Fehr A, Shi X, Quirion N, Russo B, Knight H, Aduwari A, Efimov IR, Lu L. Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology. Science Advances. 2023;9(27):eadi0757.
Review More Publications
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Center for Advanced Microscopy and Nikon Imaging Center
The Center for Advanced Microscopy (CAM) offers a variety of light and electron microscopy service, and provides Northwestern investigators access to cutting-edge imaging technologies and research expertise.
CAM’s core services include:
- Light microscopy services
- Electron microscopy services
- Image analysis support and software
Learn more about CAM
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Strengthening Integrity and Fairness in Peer Review Through New Required Trainings
Beginning for the May 2024 council round, all reviewers will be required to complete trainings related to review integrity and bias awareness prior to serving on NIH peer review groups. These trainings build on NIH’s long-standing commitment to maintain integrity and fairness throughout the review process. In this new process, there are two training modules needed to be completed. Get the full details here.
Using AI in Peer Review Is a Breach of Confidentiality
AI has been brought to the forefront of the scientific community. However, using AI Reviewers are trusted and required to maintain confidentiality throughout the application review process. Thus, using AI to assist in peer review would involve a breach of confidentiality Ensuring confidentiality means that scientists will feel comfortable sharing their candid, well-designed and thorough research ideas with the NIH. Using AI absolutely violates the NIH peer review confidentiality expectations and is thus, not permitted. Visit the NIH website to learn more.
Read the Latest from NIH
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Thank You For Reading
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