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Breakthroughs, the newsletter of the Feinberg School of Medicine Research Office

AUGUST 2023 NEWSLETTER

The newsletter of the Feinberg School of Medicine Research Office

Advancing Our Understanding Behind the Mechanisms of Pain

Today, more than 50 million adults in the U.S. suffer from chronic pain — pain lasting longer than three months — and is the most common reason why people seek medical attention, according to the Centers for Disease Control and Prevention (CDC). 

However, recent breakthroughs made by investigators at Northwestern’s Center for Translational Pain Research are moving the field forward and suggest that the brain’s emotional circuity plays a causal role in chronic pain. 

Read the Feature

Chandel Receives Prestigious Lurie Prize

Navdeep Chandel, PhD, the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care and of Biochemistry and Molecular Genetics, has been named a recipient of the 2023 Lurie Prize in Biomedical Sciences by the Foundation for the National Institutes of Health (FNIH).

Read the full story

Faculty Profile

Improving the Diagnosis and Treatment Related to Maternal-Child Health Outcomes

Jeffery Goldstein, MD, PhD, is an assistant professor of Pathology in the Divisions of Perinatal Pathology and Autopsy. For his research and clinical practice, he employs machine learning and bioinformatics to improve the health of pregnant women and their children, primarily through improved diagnosis and fundamental understanding of the placenta.

Read more about Goldstein's research

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Staff Profile

Developing Center Resources to Support Research

Carolyn Schafer, MPH, is the center administrator for the Center for Health Services and Outcomes Research at Feinberg’s Institute of Public Health and Medicine. 

Read more about Carolyn's work

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Student Profile

Translating Insights from Datasets to Improve Health

Emily Stroup is a fifth-year PhD candidate in the Driskill Graduate Program. In the lab of Zhe Ji, PhD, assistant professor of Pharmacology and McCormick School of Engineering, Stroup combines her data and computational skills with medicine to develop deep learning models to better understand polyadenylation.

Read more about Emily's research

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Campus Events

Thu
Aug 08

Assessment of Incivility During Surgical Mortality and Morbidity Conference - TIME Lecture Series - FAME

Online - 12:00 PM - 1:00 PM

Fri
Aug 09

Neurology Department Grand Rounds: Thomas Bleck, MD

Chicago - 12:00 PM - 1:00 PM

Fri
Aug 16

Pepper Center Rounds

No Location - 12:00 PM - 1:00 PM

Wed
Aug 21

Did My Learners Learn: Basic Inferential Statistics in Med Ed | FAME - Education Scholarship Session

Online - 12:00 PM - 1:00 PM

Research in the News

The Washington Post, August 8
Patients Grapple with Side Effects of Popular Weight-loss Drugs
Robert Kushner, MD, was featured.  

TIME, August 11 
Celebrities Are Getting Full-body Health Scans – Should You?
Jeff Linder, MD, was featured.  

Washington Post, August 14 
Study: Many Users of Skin-lightening Products are Unaware of Risks
Roopal Kundu, MD, was featured.  

Check out More Media Coverage

NUCATS Corner

NUCATS Regulatory Team Provides Comprehensive Study Team Support 

The Regulatory Unit of the Center for Clinical Research (CCR) can assist investigators with meeting essential regulatory activities and provides training and general support to Feinberg research staff. Services include:  

  • New IRB submission of protocols and amendments  
  • Preparation and negotiation of informed consent documents  
  • Assistance with the completion of required documentation and for monitor visits  
  • Oversight of regulatory binders (physical, E-Regulatory Files, and Complion system binders) 

Please visit our new resource page, which includes newly added Regulatory Support Guidelines, for additional information.  

Learn more about NUCATS

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Sponsored Research

Title: Time to ATTAC: Adoptive Transfer of T cells Against gp100+ Cells to treat LAM

Read more about this project

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Sponsored Research

Title: The Physiology of Store-Operated Channels in the Nervous System

Read more about this project

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Breakthroughs Podcast

Predicting Which Cancer Cells May Become Drug-Resistant with Yogesh Goyal, PhD

Treating cancer has become increasingly difficult as cells develop resistance. Northwestern investigators have sought to address this issue on the cellular level through the development of a novel FateMap tool used to predict the future behavior of cancer cells before they are exposed to cancer-fighting drugs.  

In this episode, Yogesh Goyal, PhD, discusses his latest research, published in Nature, and how his lab is addressing complex problems through an interdisciplinary approach.

Listen to the podcast episode

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New Faculty

Joshua J. Ziarek, PhD, joined Feinberg on July 1 as associate professor of Pharmacology. His research interests are in the characterization of biomolecular interactions, the molecular mechanisms of allostery and the rational design of molecular therapeutics and tools with a long-standing interest in G protein-coupled receptors (GPCRs). Previously, Ziarek was assistant professor of Cellular and Molecular Biology at Indiana University. He did his postdoctoral training at Harvard Medical School and earned his PhD from the Medical College of Wisconsin.
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Galter Library

The Power of Open Science

The federal government defines open science as “the principle and practice of making research products and processes available to all, while respecting diverse cultures, maintaining security and privacy, and fostering collaborations, reproducibility, and equity.” 

We’ve worked to support this area of need at Galter with resources, training, and services to support the Feinberg community. Highlights include the Prism Repository, classes on data management, and Galter Guides on the NIH Public Access Policy and NIH Data Management Plans.

Read the Full Story

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High Impact Research

Brastianos PK, Twohy E, Geyer S, Gerstner ER, Kaufmann TJ, Tabrizi S, Kabat B, Thierauf J, Ruff MW, Bota DA, Reardon DA, Cohen AL, De La Fuente MI, Lesser GJ, Campian J, Agarwalla PK, Kumthekar P, Mann B, Vora S, Knopp M, Iafrate AJ, Curry WT, Jr., Cahill DP, Shih HA, Brown PD, Santagata S, Barker FG, 2nd, Galanis E. BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas. New England Journal of Medicine. 2023;389(2):118-126.

Buyukcelebi K, Chen X, Abdula F, Elkafas H, Duval AJ, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Bulun SE, Wei JJ, Yue F, Adli M. Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization. Nature Communications. 2023;14(1):4057.

Cameron NA, Yee LM, Dolan BM, O'Brien MJ, Greenland P, Khan SS. Trends in Cardiovascular Health Counseling Among Postpartum Individuals. JAMA. 2023;330(4):359-367.

Chen Z, Lin Z, Obaid SN, Rytkin E, George SA, Bach C, Madrid M, Liu M, LaPiano J, Fehr A, Shi X, Quirion N, Russo B, Knight H, Aduwari A, Efimov IR, Lu L. Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology. Science Advances. 2023;9(27):eadi0757.

 

Review More Publications

Featured Core

Center for Advanced Microscopy and Nikon Imaging Center

The Center for Advanced Microscopy (CAM) offers a variety of light and electron microscopy service, and provides Northwestern investigators access to cutting-edge imaging technologies and research expertise.  

 CAM’s core services include: 

  • Light microscopy services 
  • Electron microscopy services 
  • Image analysis support and software 

Learn more about CAM

NIH News

Strengthening Integrity and Fairness in Peer Review Through New Required Trainings 

Beginning for the May 2024 council round, all reviewers will be required to complete trainings related to review integrity and bias awareness prior to serving on NIH peer review groups. These trainings build on NIH’s long-standing commitment to maintain integrity and fairness throughout the review process. In this new process, there are two training modules needed to be completed. Get the full details here.

Using AI in Peer Review Is a Breach of Confidentiality 

AI has been brought to the forefront of the scientific community. However, using AI Reviewers are trusted and required to maintain confidentiality throughout the application review process. Thus, using AI to assist in peer review would involve a breach of confidentiality Ensuring confidentiality means that scientists will feel comfortable sharing their candid, well-designed and thorough research ideas with the NIH. Using AI absolutely violates the NIH peer review confidentiality expectations and is thus, not permitted. Visit the NIH website to learn more. 

Read the Latest from NIH

Funding Opportunities

SQI Launches Seed Funding Program to Spark Nanomedicine Research 

  • Sponsor: Simpson Querrey Institute for BioNanotechnology (SQI) 
  • Deadline: September 1 
  • Upper amount: $50,000

Analyzing Early Events in TB and TB/HIV Infection for Interventional Targets (R01 Clinical Trial Not Allowed) 

  • Sponsor: National Institutes of Health, National Institute of Allergy and Infectious Diseases 
  • Letter of Intent: September 11 
  • Deadline: October 11 
  • Upper amount: Up to $500,000 over five years 

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R21 Clinical Trial Required) 

  • Sponsor: National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases 
  • Deadline: November 3 
  • Upper amount: $400,000 over three years 

More Resources

Thank You For Reading

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Breakthroughs, the newsletter of the Feinberg School of Medicine Research Office