Having trouble viewing this email? View as Webpage
Breakthroughs, the newsletter of the Feinberg School of Medicine Research Office

DECEMBER 2024 NEWSLETTER

The newsletter of the Feinberg School of Medicine Research Office

Addressing the Growing Need for Implementation Science

Translating medical research findings from the research laboratory into patient care, otherwise known as from “bench to bedside,” is far more complex than it sounds, but is imperative to improve human health. While many research programs end there, implementation science takes things a step further by moving from the bedside into the community.

Read this feature story

Feinberg Scientists Identified As ‘Highly Cited’ on 2024 Clarivate List

Ten Feinberg faculty members were named to the 2024 “Highly Cited Researchers” list, published by Clarivate Analytics. The annual list identifies investigators who have demonstrated significant influence in their field through the publication of highly cited publications over the preceding eleven years. 

Read the full story

Esteemed Molecular Biologist Named Winner of 2025 Kimberly Prize

Distinguished biochemist Ron Evans, PhD, professor and director of the Gene Expression Laboratory and March of Dimes Chair in Molecular and Developmental Biology at the Salk Institute for Biological Studies, has been named the winner of the annual $250,000 Kimberly Prize in Biochemistry and Molecular Genetics.

Read about Evans' work

Faculty Profile

Investigating the Underlying Mechanisms of Acute Lung Injury

Luisa Morales-Nebreda, MD, ’17 GME, is an assistant professor of Medicine in the Division of Pulmonary and Critical Care. As physician-scientist, her laboratory employs advanced technologies and techniques to identify novel intercellular signaling pathways between resident immune cell subsets and the injured alveolar epithelial-endothelial barrier that promote tissue repair throughout the lifespan.

Read more about her research

${image.getChild('description').value}

Staff Profile

Streamlining Research Processes to Support Investigators

Zoe Vanella is a manager of research administration in the Department of Psychiatry and Behavioral Sciences at Feinberg. In her role, Vanella empowers investigators with tools and guides to streamline research administration.

Read more about her work

${image.getChild('description').value}

Student Profile

Analyzing Host Response in Severe Pneumonia

Nikolay Markov is a PhD candidate in the Driskill Graduate Program. Now, under the guidance of Alexander Misharin, MD, PhD, and Scott Budinger, MD, he uses his skills to glean insights from large medical datasets.

Learn more about his research

${image.getChild('description').value}

Campus Events

Mon
Dec 16

Glycomic Modulation of HIV Persistence and Immunopathogenesis: Biomarkers and Therapeutic Strategies

Chicago - 12:00 PM - 1:00 PM

Tue
Dec 17

Lunch & Learn Series: Leah Welty, PhD - "Reproducible Research"

Chicago - 12:00 PM - 1:00 PM

Tue
Dec 17

SQLIFTS Distinguished Scientist Lecture Series - Dr. Maryam Valapour, MD, MPP (Speaker) - “The Science Behind the U.S. Donor Lung Allocation System”

Chicago - 12:00 PM - 1:00 PM

Tue
Dec 17

Distinguished Lecturers in Life Sciences: Spatially resolved single-cell genomics and cell atlas of the brain | Dr. Xiaowei Zhuang | Tuesday, December 17th | 3:30 pm

Chicago - 3:30 PM - 4:30 PM

Research in the News

US News & World Report, November 25
Long COVID Hits the Young Harder Than the Old, Study Finds
Igor Koralnik, MD, was featured. 

HealthDay, November 24
For Some, ‘Tis the Season for Loneliness. Experts Offer Tips to Stay Connected
Eileen Graham, PhD, was featured.

TIME, November 15
COVID-19’s Surprising Effect on Cancer
Ankit Bharat, MD, was featured.

Check out More Media Coverage

NUCATS Corner

Community of Practice for Clinical Research Staff Hosting Launch Event

A new Microsoft Teams community was formed to support clinical research staff and aims to promote educational opportunities and lectures provided by ACCR, the IRB Office, NUCATS Institute and others. Digital channel boards and a Q&A series are meant to provide greater community and conversation, as well as link to available tools and resources. Additionally, networking events will take place to support greater in-person connectivity and feedback. Please join here: Clinical Research Professional Community of Practice | General | Microsoft Teams

The Community of Practice will also be hosting an informational launch and open house on Wednesday December 18, from 12 to 1 p.m., in Ryan Family Atrium, west lobby area of the Lurie Research Building. The Microsoft Teams forum will be on display for your feedback and ideas, and light snacks and refreshments will be served. We encourage you to utilize this in-person event to network with other staff coordinating clinical research throughout Northwestern.

Join the Teams Channel

${image.getChild('description').value}

Sponsored Research

Regulation of Germinal Center Homeostasis by the BAF Complex

  • PI: Vipul Shukla, PhD, assistant professor of Cell and Developmental Biology
  • Sponsor: National Institute of Allergy and Infectious Diseases

Read more about this project

${image.getChild('description').value}

Sponsored Research

Designing for Sustainability: Co-designing and Testing the Efficacy of a Web-based Toolkit to Improve Cancer-related Emotional Distress and Anxiety for Rural Older Cancer Survivors

  • PI: Marquita Lewis, PhD, assistant professor in the Department of Medical Social Sciences
  • Sponsor: National Institute for Nursing Research

Read more about this project

${image.getChild('description').value}

Breakthroughs Podcast

Studying Social Networks to Address Health Inequities with Michelle Birkett, PhD

Understanding the systemic drivers of health disparities within marginalized populations is complex. In this episode, Birkett explains how she uses network and quantitative methodologies to study the health of marginalized populations, particularly sexual and gender minority youth. She also discusses her new center, the Center for Computational and Social Sciences in Health, and the importance of transdisciplinary research.

Listen to the podcast episode

${image.getChild('description').value}

New Faculty

Ertuğrul Özbudak, PhD

Ertuğrul Özbudak, PhD, joined Feinberg in February as Robert Laughlin Rea Professor of Anatomy and professor of Cell & Developmental Biology. He obtained his undergraduate degree in physics at Bogazici (i.e., Bosphorus) University in Istanbul. He then obtained his doctorate in physics at Massachusetts Institute of Technology. During his PhD program, he investigated the underlying causes of stochastic gene expression, the functional roles of feedback loops in generating bistability (hysteresis), triggering symmetry breaking and establishing cell polarity.

Later, he completed his postdoctoral studies in the labs of the late Julian Lewis and Olivier Pourquie. To support his studies, Özbudak received the Merck/MIT computational biology predoctoral fellowship, as well as the Cancer Research UK and Marie Curie and European Molecular Biology Organization postdoctoral fellowships. Most recently, he was selected as an Alfred P. Sloan Research Faculty Fellow. 

${image.getChild('description').value}

Galter Library

Expansion of the Clinical Librarian Service

As of this fall, the Clinical Librarian Service (CLS) offers support via chat, text and email to all Feinberg clinicians, faculty, fellows, residents and students working in inpatient and outpatient settings. 

Read the full article

${image.getChild('description').value}

High Impact Research

Abdrabou AM, Ahmed SU, Fan MJ, Duong BTV, Chen K, Lo PY, Mayes JM, Esmaeili F, GhavamiNejad A, Zargartalebi H, Atwal RS, Lin S, Angers S, Kelley SO. Identification of VISTA regulators in macrophages mediating cancer cell survival. Science Advances. November 2024; 10(48):eadq8122-eadq8122.

Bailey JI, Puritz CH, Senkow KJ, Markov NS, Diaz E, Jonasson E, Yu Z, Swaminathan S, Lu Z, Fenske S, Grant RA, Abdala-Valencia H, Mylvaganam RJ, Ludwig A, Miller J, Cumming RI, Tighe RM, Gowdy KM, Kalhan R, Jain M, Bharat A, Kurihara C, San Jose Estepar R, San Jose Estepar R, Washko GR, Shilatifard A, Sznajder JI, Ridge KM, Budinger GRS, Braun R, Misharin AV, Sala MA. Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19. Nature Immunology. November 2024; 25(11):2097-2109.

Becker ME, Martin-Sancho L, Simons LM, McRaven MD, Chanda SK, Hultquist JF, Hope TJ. Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread. Nature Communications. November 2024; 15(1):9480-9480.

Beidas RS, Linn KA, Boggs JM, Marcus SC, Hoskins K, Jager-Hyman S, Johnson C, Maye M, Quintana L, Wolk CB, Wright L, Pappas C, Beck A, Bedjeti K, Buttenheim AM, Daley MF, Elias M, Lyons J, Martin ML, McArdle B, Ritzwoller DP, Small DS, Williams NJ, Zhang S, Ahmedani BK. Implementation of a Secure Firearm Storage Program in Pediatric Primary Care: A Cluster Randomized Trial. JAMA Pediatrics. November 2024; 178(11):1104-1113.

Review More Publications

Featured Core

Biostatistics Collaboration Center

The mission of the Stem Cell Core Facility is to enable scientists at Northwestern to conduct stem cell research, particularly with induced pluripotent stem cells (iPSCs). Patient-specific iPSCs offer unprecedented opportunities to study human developmental processes and disease, using human stem cell-derived somatic cells under each person’s unique genetic constellation. They also represent a unique and very important source of cells for cell replacement therapy.

The mission of the Biostatistics Collaboration Center (BCC) is to support Feinberg investigators in the conduct of high-quality, innovative health-related research by providing expertise in biostatistics, statistical programming, and data management.

Services Provided

  • The BCC faculty and staff are eager to help you meet the statistical needs of your research. Our areas of expertise include but are not limited to:
    • Bayesian Methods
    • Big Data
    • Bioinformatics
    • Causal inference
    • Clinical trials
    • Cluster analysis
    • Database design
    • Genomics
    • Longitudinal data
    • Machine learning
    • Missing data
    • Reproducibility
    • Statistical genetics
    • Survival analysis
    • Wearable data

Learn more about the BCC

NIH News

Preparing for 2025 Application and Review Changes – Tips and Resources 

As everyone prepares for application dates for January due dates and beyond, NIH issued a reminder that multiple changes affecting extramural applications and reviews are coming. These changes and resources include:  

NIH All About Grants Podcast: Fellowships and What’s Changing 

The applications and peer review processes are changing for fellowship applications due on or after January 25, 2025. These changes aim to better focus reviewers on the fellowship candidate’s preparedness and potential, research training plan, and commitment to the candidate; clarify and simplify language in the application and review criteria to ensure a broader range of candidates and research training contexts; and emphasize commitment to the candidate without undue consideration of sponsor and institutional reputation to reduce potential bias during review. Listen to a recent episode of NIH’s All About Grants Podcast. 

Read the Latest from NIH

Funding Opportunities

Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R01 Clinical Trial Not Allowed) 

  • Sponsor: NIH, National Cancer Institute (NCI) 
  • Deadline: February 5 
  • Upper amount: Application budgets are not limited but needed to reflect the actual needs of the proposed project  

Innovative Pilot Mental Health Services Research Not Involving Clinical Trials (R34 Clinical Trial Not Allowed) 

  • Sponsor: NIH, National Institute of Mental Health (NIMH) 
  • Deadline: February 16 
  • Upper amount: Direct costs are limited to $450,000 over the 3-year R34 project period, with no more than $225,000 in direct costs allowed in any one year  

Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial Optional) 

  • Sponsor: NIH, National Institute on Drug Abuse (NIDA) 
  • Deadline: March 20 
  • Upper amount: Direct costs are limited to $450,000 over the 3-year R34 project period, with no more than $225,000 in direct costs allowed in a single year 

Thank You For Reading

We welcome your feedback. Please share it with us via email.

Breakthroughs, the newsletter of the Feinberg School of Medicine Research Office