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Exploring host-pathogen interactions and immunological mechanisms.

 

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Recent Publications

The alphaherpesvirus gE/gI glycoprotein complex and proteases jointly orchestrate invasion across the host's upper respiratory epithelial barrier.

Van Crombrugge E, Ren X, Glorieux S, Zarak I, Van den Broeck W, Bachert C, Zhang N, Van Zele T, Kim D, Smith GA, Laval K, Nauwynck H.

mBio. 2024 Nov 13;15(11):e0187324. doi: 10.1128/mbio.01873-24. Epub 2024 Oct 9.

Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming.

Kim D, Kim G, Yu R, Lee J, Kim S, Gleason MR, Qiu K, Montauti E, Wang LL, Fang D, Choi J, Chandel NS, Weinberg S, Min B.

Immunity. 2024 Nov 12;57(11):2634-2650.e5. doi: 10.1016/j.immuni.2024.08.008. Epub 2024 Sep 4.

Structures of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features.

Zhen J, Chen J, Huang H, Liao S, Liu S, Yuan Y, Sun R, Longnecker R, Wu T-T, Zhou ZH.

J Virol. 2024 Oct 29:e0119424. doi: 10.1128/jvi.01194-24. Online ahead of print.

Delayed reinforcement of costimulation improves the efficacy of mRNA vaccines in mice.

Sanchez S, Dangi T, Awakoaiye B, Lew MH, Irani N, Fourati S, Penaloza-MacMaster P.

J Clin Invest. 2024 Oct 17:e183973. doi: 10.1172/JCI183973. Online ahead of print.

Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems.

Maddineni A, Liang Z, Jambardi S, Roy S, Tycko J, Patil A, Manzano M, Gottwein E.

bioRxiv [Preprint]. 2024 Sep 23:2024.09.23.614524. doi: 10.1101/2024.09.23.614524.

What We Do

Welcome to the Department of Microbiology-Immunology, a basic science department at Northwestern University Feinberg School of Medicine. Our dedicated faculty are experts in the areas of bacteriology, virology and immunology and guide the training of our students and postdoctoral fellows. Learn more below.

Research

We examine pathogen-host cell interactions and dissect the molecular mechanisms involved in regulation of the immune response. 
EXPLORE OUR AREAS OF FOCUS

Education

Our faculty members also teach undergraduate, graduate and medical students at Northwestern University and Feinberg.
SEE TRAINING OPPORTUNITIES

Center for Structural Biology of Infectious Diseases

The Center for Structural Biology of Infectious Diseases (CSBID) is a consortium of laboratories using state-of-the-art, high-throughput structural biology methods to determine the three-dimensional structures of protein targets from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases.

VISIT THE CSBID SITE

Basic Science Administration

Our department is supported by the Basic Science Administration group. The team provides assistance related to research and financial administration, professional affairs, facilities and communications.

VISIT BASIC SCIENCE ADMINISTRATION SITE

Research Resources

We offer a wide range of resources, mentorship opportunities and training to help our residents and fellows excel as physician-scientists. Explore all of the resources and hear from housestaff who are making research a major part of their career development plans.

VISIT THE Starzl Academy Site