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Tsioras K, Smith KC, Edassery SL, Garjani M, Li Y, Williams C, McKenna ED, Guo W, Wilen AP, Hark TJ, Marklund SL, Ostrow LW, Gilthorpe JD, Ichida JK, Kalb RG, Savas JN, Kiskinis E. Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis . Cell Rep. 2023 Oct 31;42(10):113160. doi: 10.1016/j.celrep.2023.113160. Epub 2023 Sep 29. PMID: 37776851; PMCID: PMC10785776.
Vanecek AS, Mojsilovic-Petrovic J, Kalb RG, Tepe JJ. Enhanced Degradation of Mutant C9ORF72 -Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection. ACS Chem Neurosci. 2023 Apr 4. doi: 10.1021/acschemneuro.2c00732. Epub ahead of print. PMID: 37015082.
Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG. Neurons undergo pathogenic metabolic reprogramming in models of familial ALS . Mol Metab. 2022 Jun;60:101468. doi: 10.1016/j.molmet.2022.101468. Epub 2022 Mar 3. PMID: 35248787; PMCID: PMC8958550.
Snoznik C, Medvedeva V, Mojsilovic-Petrovic J, Rudich P, Oosten J, Kalb RG, Lamitina T. The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity . Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2104664118. doi: 10.1073/pnas.2104664118. Epub 2021 Sep 30. PMID: 34593637; PMCID: PMC8501779.
Yoonseok Park, Colin K. Franz, Hanjun Ryu, Haiwen Luan, ..., Kristen Y. Cotton Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids Sci Adv . 2021 Mar 17;7(12):eabf9153. doi: 10.1126/sciadv.abf9153.
E'anna B. Ryan, Jianhua Yan, Nimrod Miller, Sudarshan Dayanidhi, Yongchao C. Ma, Han-Xiang Deng, Teepu Siddique Early death of ALS-linked CHCHD10-R15Ltransgenic mice with central nervous system, skeletal muscle, and cardiac pathology iScience 2021 Jan 18;24(2):102061. doi: 10.1016/j.isci.2021.102061
Juan A. Ortega, Elizabeth L. Daley, Sukhleen Kour, ..., Jeffrey N. Savas, Udai B. Pandey, Evangelos Kiskinis Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity Neuron 2020 Apr 8;106(1):90-107.e13. doi: 10.1016/j.neuron.2020.01.020
Ozdinler PH Expanded access: opening doors to personalized medicine for rare disease patients and patients with neurodegenerative diseases. FEBS J 2020 Aug 17;. doi:10.1111/febs.15529
Özdinler PH Help from peripheral macrophages in ALS? Nat Neurosci 2020 11;23(11):1311-1312. doi:10.1038/s41593-020-00727-y
Brent JR, Franz CK, Coleman JM, Ajroud-Driss S ALS: Management Problems. Neurol Clin 2020 08;38(3):565-575. pii:S0733-8619(20)30034-7
Burt RK, Balabanov R, Tavee J, Han X, Sufit R, Ajroud-Driss S, Jovanovic B, Quigley K, Arnautovic I, Helenowski I, Sharrack B Hematopoietic stem cell transplantation for chronic inflammatory demyelinating polyradiculoneuropathy. J Neurol 2020 Nov;267(11):3378-3391. doi:10.1007/s00415-020-10010-6
Genc B, Gozutok O, Kocak N, Ozdinler PH The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord. Cells 2020 02 22;9(2). pii:E502
Deng S, Feely SME, Shi Y, Zhai H, Zhan L, Siddique T, Deng HX, Shy ME Incidence and Clinical Features of TRPV4-Linked Axonal Neuropathies in a USA Cohort of Charcot-Marie-Tooth Disease Type 2. Neuromolecular Med 2020 03;22(1):68-72. doi:10.1007/s12017-019-08564-4
Genc B, Gozutok O, Ozdinler PH Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons. Int J Mol Sci 2019 Aug 07;20(16). pii:E3848
Deng HX HACE1, RAC1, and what else in the pathogenesis of SPPRS? Neurol Genet 2019 Jun;5(3):e326. doi:10.1212/NXG.0000000000000326
Franz CK, Joshi D, Daley EL, Grant RA, Dalamagkas K, Leung A, Finan JD, Kiskinis E Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench. J Neurophysiol 2019 09 01;122(3):1174-1185. doi:10.1152/jn.00572.2018
Deng HX, Pericak-Vance MA, Siddique T Reply to 'TMEM230 variants in Parkinson's disease' and 'Doubts about TMEM230 as a gene for parkinsonism'. Nat Genet 2019 03;51(3):369-371. doi:10.1038/s41588-019-0355-5
Kristen AV, Ajroud-Driss S, Conceição I, Gorevic P, Kyriakides T, Obici L Patisiran, an RNAi therapeutic for the treatment of hereditary transthyretin-mediated amyloidosis. Neurodegener Dis Manag 2019 02;9(1):5-23. doi:10.2217/nmt-2018-0033
Aubert G, Ajroud-Driss S, Knight BP, Shah SJ, McNally EM New DEStiny Revealed: Young Woman Postablation for Wolf-Parkinson-White Syndrome With Recurrent Syncope and Progressive Myopathy. Circulation 2018 09 18;138(12):1267-1271. doi:10.1161/CIRCULATIONAHA.118.035577
Simkin D, Kiskinis E Modeling Pediatric Epilepsy Through iPSC-Based Technologies. Epilepsy Curr ;18(4):240-245. doi:10.5698/1535-7597.18.4.240
Franz CK, Puritz A, Jordan LA, Chow J, Ortega JA, Kiskinis E, Heckman CJ Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models. Neurorehabil Neural Repair 2018 08;32(8):735-745. doi:10.1177/1545968318790020
Kiskinis E, Kralj JM, Zou P, Weinstein EN, Zhang H, Tsioras K, Wiskow O, Ortega JA, Eggan K, Cohen AE All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS. Stem Cell Reports 2018 06 05;10(6):1991-2004. pii:S2213-6711(18)30188-7
McDermott MM, Peterson CA, Sufit R, Ferrucci L, Guralnik JM, Kibbe MR, Polonsky TS, Tian L, Criqui MH, Zhao L, Stein JH, Li L, Leeuwenburgh C Peripheral artery disease, calf skeletal muscle mitochondrial DNA copy number, and functional performance. Vasc Med 2018 08;23(4):340-348. doi:10.1177/1358863X18765667
Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N. Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. Nat Immunol. 2020 Feb;21(2):158-167. doi: 10.1038/s41590-019-0569-9. Epub 2020 Jan 13. PMID: 31932809; PMCID: PMC6983345.
Bennett HL, McClanahan PD, Fang-Yen C, Kalb RG. Preconditioning of Caenorhabditis elegans to anoxic insult by inactivation of cholinergic, GABAergic and muscle activity. Genes Brain Behav. 2020 Nov 5:e12713. doi: 10.1111/gbb.12713. Epub ahead of print. PMID: 33155386.