Surveillance on Anticoagulants Prescription, Risk of Stroke and Bleeding by Geographic Region and Race in the US

Oral anticoagulation (OAC) therapy reduces the risk of thromboembolic events associated with atrial fibrillation (AF), yet a substantial proportion of patients with AF are not prescribed OAC. The wide geographic coverage of the clinical data from the National Patient-Centered Clinical Research Network (PCORnet) provides a unique opportunity to explore regional variation in the prescription of medications and the associated risk of diseases. Utilizing electronic health record data from four PCORnet Clinical Data Research Networks (CAPriCORN, REACHnet, STAR, and ADVANCE) that cover several states, we will perform spatial investigation to assess correlation between racial disparity in the prescription of OAC and incidence of stroke and major bleeding across census tracts, states, and regions of the Unites States in patients newly diagnosed with atrial fibrillation.

Principal Investigator:
Yacob Tedla, PhD

Co-Investigators/ Mentors:
Abel Kho, MD
Philip Greenland, MD
Rod Passman, MD

Funding:
Funding for this grant is provided by the Patient-Centered Outcomes Research Institute (PCORI) through Harvard Pilgrim Health Care Institute.

Timeline:
2019 – 2020