I-I-CAPTAIN

Guideline-directed medical therapy (GDMT) for patients with reduced ejection fraction (HFrEF) improves quality of life, reduces hospitalizations, and extends survival. However, busy clinicians treating stable patients with chronic diseases often "leave well enough alone." This clinical inertia results in GDMT underuse and frequently does not align with patient health preferences.

The I-I-CAPTAIN (Implementation and Interaction of Clinician and Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart Failure with Reduced Ejection Fraction) trial will implement and test patient-facing and clinician-facing nudges for HFrEF medication intensification at five health systems around the country through a randomized, implementation-effectiveness trail.

The results of this pragmatic trial will answer broad questions related to decision support for evidence-based care, including whether patient-facing or clinician-facing decision support tools are more effective or if the two approaches are additive or synergistic. Ultimately, the trial aims to identify scalable strategies that promote the equitable uptake of evidence-based therapies. 

NM Collaborators:
NM Information Services

External Collaborators:
University of Colorado (Lead Site)
Yale University
University of Utah
Sutter Health

Funding:
Patient-Centered Outcomes Research Institute

Timeline:
2024-2029