Publications

1. Shilatifard A  The dire need for federal support of molecular research, then and now.  Sci Adv  2022 Jun 10;8(23):eadd1030. doi:10.1126/sciadv.add1030
2. Di Meco A, Kemal S, Popovic J, Chandra S, Sadleir KR, Vassar R  Poloxamer-188 Exacerbates Brain Amyloidosis, Presynaptic Dystrophies, and Pathogenic Microglial Activation in 5XFAD Mice.  Curr Alzheimer Res  2022 May 09;. doi:10.2174/1567205019666220509143823
3. Upadhyay A, Vassar RJ, Savas JN  Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain.  J Vis Exp  2022 04 28;(182). doi:10.3791/63816
4. Kim S, Coukos R, Gao F, Krainc D  Dysregulation of organelle membrane contact sites in neurological diseases.  Neuron  2022 May 06;. pii:S0896-6273(22)00365-8
5. Rawat R, Tunc-Ozcan E, McGuire TL, Peng CY, Kessler JA  Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice.  Nat Commun  2022 May 12;13(1):2650. doi:10.1038/s41467-022-30386-5
6. Bhuiyan ZA, Bdier A, Al-Aama JY, Abramova T, George AL  Discordance Between Germline and Blood Mosaicism in Calmodulinopathy.  Circ Genom Precis Med  2022 May 11;:101161CIRCGEN121003695. doi:10.1161/CIRCGEN.121.003695
7. Piunti A, Shilatifard A  Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer.  Nat Rev Mol Cell Biol  2022 Jun;23(6):444. doi:10.1038/s41580-022-00495-6
8. Cenik BK, Sze CC, Ryan CA, Das S, Cao K, Douillet D, Rendleman EJ, Zha D, Khan NH, Bartom E  et al.  A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells.  Proc Natl Acad Sci U S A  2022 05 10;119(19):e2118385119. doi:10.1073/pnas.2118385119
9. Cao TQ, Harris GR, Lineback CM, Sokol LL, Mencacci N, Opal P  Clinical Reasoning: A 77-Year-Old Man With Involuntary Movements, Sleep Changes, Falls, Bulbar Symptoms, and Cognitive Complaints.  Neurology  2022 Apr 29;. pii:10.1212/WNL.0000000000200705
10. Tanimura A, Shen W, Wokosin D, Surmeier DJ  Pathway-Specific Remodeling of Thalamostriatal Synapses in a Mouse Model of Parkinson's Disease.  Mov Disord  2022 Jun;37(6):1164-1174. doi:10.1002/mds.29030
11. Mesulam MM, Coventry CA, Bigio EH, Sridhar J, Gill N, Fought AJ, Zhang H, Thompson CK, Geula C, Gefen T  et al.  Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia.  Brain  2022 Apr 20;. pii:awab410
12. Simkin D, Ambrosi C, Marshall KA, Williams LA, Eisenberg J, Gharib M, Dempsey GT, George AL, McManus OB, Kiskinis E  'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies.  Trends Pharmacol Sci  2022 05;43(5):392-405. pii:S0165-6147(22)00051-7
13. Shilatifard A  On Healthy Scientific Debates.  Sci Adv  2022 Apr;8(13):eabq1534. doi:10.1126/sciadv.abq1534
14. Gertler TS, Cherian S, DeKeyser JM, Kearney JA, George AL  KNa1.1 gain-of-function preferentially dampens excitability of murine parvalbumin-positive interneurons.  Neurobiol Dis  2022 06 15;168:105713. pii:S0969-9961(22)00105-X
15. Henderson MX, Henrich MT, Geibl FF, Oertel WH, Brundin P, Surmeier DJ  The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease.  Neurobiol Dis  2022 06 15;168:105687. pii:S0969-9961(22)00078-X
16. Simkin D, Papakis V, Bustos BI, Ambrosi CM, Ryan SJ, Baru V, Williams LA, Dempsey GT, McManus OB, Landers JE  et al.  Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls.  Stem Cell Reports  2022 04 12;17(4):993-1008. pii:S2213-6711(22)00097-2
17. Shen W, Zhai S, Surmeier DJ  Striatal synaptic adaptations in Parkinson's disease.  Neurobiol Dis  2022 06 01;167:105686. pii:S0969-9961(22)00077-8
18. Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G  et al.  Neurons undergo pathogenic metabolic reprogramming in models of familial ALS.  Mol Metab  2022 Jun;60:101468. pii:S2212-8778(22)00037-0
19. Bomba-Warczak E, Savas JN  Long-lived mitochondrial proteins and why they exist.  Trends Cell Biol  2022 Feb 24;. pii:S0962-8924(22)00034-4
20. King A, Gerard EE  Contraception, fecundity, and pregnancy in women with epilepsy: an update on recent literature.  Curr Opin Neurol  2022 04 01;35(2):161-168. doi:10.1097/WCO.0000000000001039
21. Kim MJ, Jeong H, Krainc D  Lysosomal ceramides regulate Cathepsin B-mediated processing of saposin C and glucocerebrosidase activity.  Hum Mol Genet  2022 Feb 19;. pii:ddac047
22. González-Rodríguez P, Zampese E, Stout KA, Guzman JN, Ilijic E, Yang B, Tkatch T, Stavarache MA, Wokosin DL, Gao L  et al.  Author Correction: Disruption of mitochondrial complex I induces progressive parkinsonism.  Nature  2022 Mar;603(7899):E1. doi:10.1038/s41586-021-04382-6
23. Wang L, Birch NW, Zhao Z, Nestler CM, Kazmer A, Shilati A, Blake A, Ozark PA, Rendleman EJ, Zha D  et al.  Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia.  Nat Cancer  2021 05;2(5):515-526. doi:10.1038/s43018-021-00199-4
24. Sadleir KR, Popovic J, Khatri A, Vassar R  Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis.  PLoS One  2022;17(2):e0263332. doi:10.1371/journal.pone.0263332
25. Vanoye CG, Desai RR, Ji Z, Adusumilli S, Jairam N, Ghabra N, Joshi N, Fitch E, Helbig KL, McKnight D  et al.  High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity.  JCI Insight  2022 03 08;7(5). doi:10.1172/jci.insight.156314
26. Francelle L, Mazzulli JR  Neuroinflammation in Gaucher disease, neuronal ceroid lipofuscinosis, and commonalities with Parkinson's disease.  Brain Res  2022 04 01;1780:147798. pii:S0006-8993(22)00022-1
27. Simuni T, Okun MS  Adjunctive Therapies in Parkinson Disease-Have We Made Meaningful Progress?  JAMA Neurol  2022 02 01;79(2):119-120. doi:10.1001/jamaneurol.2021.4140
28. Tunc-Ozcan E, Brooker SM, Bonds JA, Tsai YH, Rawat R, McGuire TL, Peng CY, Kessler JA  Hippocampal BMP signaling as a common pathway for antidepressant action.  Cell Mol Life Sci  2021 Dec 22;79(1):31. doi:10.1007/s00018-021-04026-y
29. Fredriksen K, Aivazidis S, Sharma K, Burbidge KJ, Pitcairn C, Zunke F, Gelyana E, Mazzulli JR  Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo.  Proc Natl Acad Sci U S A  2021 12 14;118(50). pii:e2108489118
30. Grant J, Kimmel BR, Szymczak LC, Roll J, Mrksich M  Characterizing Enzyme Cooperativity with Imaging SAMDI-MS.  Chemistry  2022 Feb 24;28(12):e202103807. doi:10.1002/chem.202103807
31. Morgan MAJ, Popova IK, Vaidya A, Burg JM, Marunde MR, Rendleman EJ, Dumar ZJ, Watson R, Meiners MJ, Howard SA  et al.  A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.  Genes Dev  2021 12 01;35(23-24):1642-1656. doi:10.1101/gad.348766.121
32. Frederick NM, Pooler MM, Shah P, Didonna A, Opal P  Pharmacological perturbation reveals deficits in D2 receptor responses in Thap1 null mice.  Ann Clin Transl Neurol  2021 12;8(12):2302-2308. doi:10.1002/acn3.51481
33. Stojkovska I, Wani WY, Zunke F, Belur NR, Pavlenko EA, Mwenda N, Sharma K, Francelle L, Mazzulli JR  Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking.  Neuron  2022 02 02;110(3):436-451.e11. pii:S0896-6273(21)00862-X
34. Earley AM, Burbulla LF, Krainc D, Awatramani R  Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons.  Sci Rep  2021 11 15;11(1):22257. doi:10.1038/s41598-021-01366-4
35. Surmeier DJ, Nguyen JT, Lancki N, Venuto CS, Oakes D, Simuni T, Wyse RK  Re-Analysis of the STEADY-PD II Trial-Evidence for Slowing the Progression of Parkinson's Disease.  Mov Disord  2022 02;37(2):334-342. doi:10.1002/mds.28850
36. Pereira Luppi M, Azcorra M, Caronia-Brown G, Poulin JF, Gaertner Z, Gatica S, Moreno-Ramos OA, Nouri N, Dubois M, Ma YC  et al.  Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins.  Cell Rep  2021 11 09;37(6):109975. pii:S2211-1247(21)01454-6
37. Larson D, Simuni T  New dopaminergic therapies for PD motor complications.  Neuropharmacology  2022 02 15;204:108869. pii:S0028-3908(21)00424-X
38. González-Rodríguez P, Zampese E, Stout KA, Guzman JN, Ilijic E, Yang B, Tkatch T, Stavarache MA, Wokosin DL, Gao L  et al.  Disruption of mitochondrial complex I induces progressive parkinsonism.  Nature  2021 11;599(7886):650-656. doi:10.1038/s41586-021-04059-0
39. Kimmel BR, Mrksich M  Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly.  Chemistry  2021 Dec 20;27(71):17843-17848. doi:10.1002/chem.202103059
40. Carvill GL, Matheny T, Hesselberth J, Demarest S  Haploinsufficiency, Dominant Negative, and Gain-of-Function Mechanisms in Epilepsy: Matching Therapeutic Approach to the Pathophysiology.  Neurotherapeutics  2021 07;18(3):1500-1514. doi:10.1007/s13311-021-01137-z
41. Burbulla LF, Zheng J, Song P, Jiang W, Johnson ME, Brundin P, Krainc D  Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models.  JCI Insight  2021 10 08;6(19). doi:10.1172/jci.insight.148649
42. Ysselstein D, Young TJ, Nguyen M, Padmanabhan S, Hirst WD, Dzamko N, Krainc D  Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity.  Mov Disord  2021 12;36(12):2719-2730. doi:10.1002/mds.28815
43. Zunke F, Winner B, Richter F, Caraveo G  Editorial: Intracellular Mechanisms of α-Synuclein Processing.  Front Cell Dev Biol  2021;9:752378. doi:10.3389/fcell.2021.752378
44. Brooker SM, Krainc D  Glucocerebrosidase dysfunction in neurodegenerative disease.  Essays Biochem  2021 12 22;65(7):873-883. doi:10.1042/EBC20210018
45. Aoi Y, Takahashi YH, Shah AP, Iwanaszko M, Rendleman EJ, Khan NH, Cho BK, Goo YA, Ganesan S, Kelleher NL  et al.  SPT5 stabilization of promoter-proximal RNA polymerase II.  Mol Cell  2021 11 04;81(21):4413-4424.e5. pii:S1097-2765(21)00646-8
46. Bai T, Peng CY, Aneas I, Sakabe N, Requena DF, Billstrand C, Nobrega M, Ober C, Parast M, Kessler JA  Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts.  Stem Cell Res  2021 10;56:102507. pii:S1873-5061(21)00354-8
47. Shilatifard A  Expanding the breadth and depth of Science Advances.  Sci Adv  2021 Aug;7(34). pii:eabl3664
48. Surmeier DJ  Beyond Just Connectivity - Neuronal Activity Drives α-Synuclein Pathology.  Mov Disord  2021 07;36(7):1487-1488. doi:10.1002/mds.28618