Funded Research Projects
See below for a list of our research team's ongoing, funded atrial fibrillation (AFib) research projects.
MRI of diffuse left ventricular fibrosis in AFib
Funding source: NIH 1R01HL116895
PI: Kim
To develop a novel MRI method to quantify diffuse left ventricular fibrosis in patients who are undergoing AFib ablation, for prediction of LV functional improvement after ablation
MRI of left atrial hemodynamic disorder in AFib
Funding source: NIH 1R21AG055954
PI: Kim/Markl
To develop a new imaging test needed for establishing a risk stratification system based on physiologic factors in thrombus formation
Left atrial 4D hemodynamics and thromboembolic risk in AFib
Funding source: AHA Grant-in-Aid 12GRNT12080032
Co-PI: Markl/Lee
To assess 4D flow magnetic resonance imaging (MRI) methods as a risk factor for thrombus formation in AFib
4D magnetic resonance imaging for atrial flow assessment in AFib
Funding source: NIH 1R21HL113895-01A1
PI: Lee/Markl
To quantify blood flow in the right and left atria in AFib
AFib burden, vascular disease of the brain and cardiac MRI in MESA
Funding source: NIH via Univ of Washington 5R01HL127659-02
PI: Greenland
To assess AFib in relation to cerebral and cardiac structure and function and cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA)
Midwest Regional Center Women’s Health Initiative Extension 2015-2020
Funding source: NIH via Ohio State HHSN268201100002C
PI: Greenland
To perform ancillary studies on WHI dataset, engage other investigators, and mentor new scientists on the WHI resource; AFib is one of the outcomes tracked by the study and this resource has led to the WHISH-STAR project
Multi-Ethnic Study of Atherosclerosis (MESA) Chicago Field Center – Task 1
Funding source: NIH via Univ of Washington HHSN268201500003I
PI: Greenland
To examine factors associated with progression of subclinical CVD and identify high-risk asymptomatic persons for preventive measures; MESA has provided a laboratory for population studies of AFib, and more than 50 papers on AFib have been published so far
Validation of an AFib-sensing smartwatch algorithm
Funding source: AliveCor
PI: Passman
To validate the accuracy of an AFib-sensing smarthwatch for AFib detection
The impact of race/ethnicity differences on novel oral anticoagulant ultization, stroke outcomes and bleeding risks
Funding source: Bristol-Myers Squibb Company
PI: Passman/Greenland
To evaluate in stroke and bleeding risk in minorities with AFib
The WHI Strong and Heathy SilenT Atrial Fibrillation Recording Study (WHISH STAR)
Funding source: NIH via Stanford R01HL136390-01
Co-I: Greenland
To measure the effect of physical activity intervention on incident AFib and the effect of AFib screening on rates of anticoagulant use in high-risk women
The role of Pak1 in the development of AFib
Funding source: NIH R01HL128330
Co-I: Arora
To understand the role of Pak-1 signaling in the creation of substrate for triggered activity in AFib
Electrogram morphology recurrence identifies areas of consistent activation directions and rotor activity in a canine model of AFib
Funding source: AHA 12GRNT12070241
PI: Arora
To determine novel measure of electrogram morphology (Electrogram Morphology Recurrence) can help identify sites of driver rotors in AFib
Oxidative stress contributes to AFib by causing remodeling of the autonomic nervous system
NIH (NHLBI) RO1 R01HL140061
PI: Arora
To determine whether oxidative stress creates substrate for atrial fibrillation by causing structural and functional remodeling of the autonomic nervous system