News and Announcements
Read the latest news from Simpson Querrey Institute for Epigenetics. The links below take you to articles where you can learn more about our faculty’s latest achievements, awards, and honors.
12.18.2024A new study has provided direct evidence in mice that the drug reversibly cuts the cell’s energy supply by interfering with mitochondria to lower glucose levels.
12.12.2024Northwestern University scientists have designed a new implantable device that can monitor fluctuating levels of proteins within the body in real time.
12.09.2024Distinguished biochemist Ron Evans, PhD, director of the Gene Expression Laboratory and professor at the Salk Institute for Biological Studies, has been named the winner of the annual $250,000 Kimberly Prize in Biochemistry and Molecular Genetics.
10.17.2024Northwestern Medicine scientists have discovered how a protein in a deadly type of lung cancer can control how the immune system responds to the tumor, according to a study published in the Proceedings of the National Academy of Sciences.
08.21.2024Scientists have discovered how interactions between RNA and the TOP1 essential enzyme, which is overexpressed in many human cancers, regulate DNA during transcription and may inform the creation of new cancer therapies, according to a Northwestern Medicine study published in Molecular Cell.
08.08.2024Investigators from the laboratory of Marc Mendillo, PhD, have discovered new cellular regulators of an established cancer cell transcription factor linked to cancer cell resilience and tumor progression, according to findings published in the Proceedings of the National Academy of Sciences.
08.01.2024Northwestern Medicine scientists have discovered new insights into the production and regulation of an emerging class of noncoding RNAs in three major types of cancer, according to findings published in Science Advances.
07.26.2024Northwestern Medicine scientists have discovered increased immune cell activity in Merkel cell carcinoma tumors, which could help predict treatment response in patients and inform the development of new targeted therapies, according to findings published in the journal Cancer Discovery.
07.25.2024Northwestern Medicine scientists have discovered that mitochondria are not necessary for the proliferation of immune cells called microglia, but do help them respond to demyelinating injury, according to a study published in Nature Metabolism.
06.24.2024Inflamed heart muscles can mount immune responses even in the absence of immune cells, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.
05.01.2024A multiprotein complex is essential for regulating cellular transcription response to oxygen deprivation, a key feature of cancer, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences.
04.17.2024A multi-institutional team of investigators have developed a new framework for supporting healthcare providers in implementing polygenic risk score-based testing into primary care settings, according to a recent study published in Nature Medicine.
04.16.2024Influential biochemist Craig M. Crews, PhD, who pioneered the pharmaceutical field of targeted protein degradation, delivered the second Kimberly Prize in Biochemistry and Molecular Genetics Lecture to a full auditorium of Feinberg faculty, staff, fellows and students.
04.10.2024Northwestern Medicine investigators have discovered that inhibiting a chromatin remodeling complex associated with a particular gene in small-cell lung cancer cells may decrease cancer cell differentiation and tumor growth, according to findings published in Nature Communications.
04.04.2024The lab of Yongchao C. Ma, PhD, has discovered a fundamental biological mechanism that could lead to new treatments for neurological diseases, such as spinal muscular atrophy (SMA) and autism, as well as different cancers.
03.28.2024Investigators led by Issam Ben-Sahra, PhD, have discovered how cellular metabolism fluctuates in response to changes in levels of pyrimidines, metabolites used by cells to make DNA and RNA, according to a recent study published in Science.
01.18.2024A multidisciplinary team of investigators has developed a first-of-its-kind interactive 3D spatial approach that reveals new therapeutic targets and provides a comprehensive three-dimensional view of glioblastoma tumors, detailed in a recent study published in Cell.
01.16.2024Investigators led by Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine, have discovered previously unknown protein interactions in the heart’s atrium that are critical for normal heart function, according to findings published in the Proceedings of the National Academy of Sciences.
01.05.2024Some strains of an antibiotic-resistant bacteria may not turn out to be as aggressive as previously thought, according to a Northwestern Medicine study recently published in Nature Communications.
12.20.2023Northwestern Medicine investigators have successfully localized novel molecular mechanisms behind a genetic mutation found in a wide range of cancers, which could serve as a biomarker for improving patient stratification and treatment, according to findings published in Proceedings of the National Academy of Sciences.
12.05.2023Northwestern University Feinberg School of Medicine and the Simpson Querrey Institute for Epigenetics announced today that renowned biochemist Craig M. Crews, PhD, who pioneered the pharmaceutical field of targeted protein degradation, has been named the winner of the annual $250,000 Kimberly Prize in Biochemistry and Molecular Genetics.
11.22.2023Investigators from the laboratory of Ali Shilatifard, PhD, have discovered a new repeat gene cluster sequence that is exclusively expressed in humans and non-human primates, according to findings published in Science Advances.
11.16.2023A new molecular technology capable of binding to mRNA and regulating gene expression may offer a new avenue for treating diseases caused by insufficient protein levels, according to a study published in Nature Communications.
11.09.2023Investigators led by Neil Kelleher, PhD, have developed an automated technique for imaging proteoforms in ovarian cancer, according to results published in Nature Communications.
11.02.2023In a recent article published in Molecular Cell, the laboratory of Ali Shilatifard, PhD, provided a comprehensive overview of the current understanding of the elongation stage of DNA transcription and how its dysregulation is associated with developmental defects, disease and aging.
09.26.2023A multi-institutional team of investigators including Northwestern University scientists has received $45 million to fast-track the development of a first-of-its-kind implant to sense and treat cancer.
- 09.20.2023
Northwestern Medicine investigators have discovered how the PD-1 protein controls essential metabolic processes in tumor cells to promote cancer growth in T-cell non-Hodgkin lymphomas, according to a study published in Nature Cancer.
09.11.2023Northwestern Medicine scientists have developed an engineered probiotic capable of detecting inflammatory bowel disease, according to a study published in the Proceedings of the National Academy of Sciences.
09.06.2023Naturally occurring variations near the human gene CHD1L may be linked to lower HIV-1 viral load in people of African ancestry, according to a new international, multicenter study published in Nature.