News and Announcements

Northwestern Medicine investigators have developed a new avenue to reprogram compromised immune cells to work against tumors, according to a study published in Science Advances.

Northwestern Medicine scientists have uncovered a key pathway controlling tumor growth in B-cell lymphomas, according to a study published in the Journal of Clinical Investigation.

Investigators have developed a catalog of transcription factor binding sites that regulate gene expression across the genome, findings that may improve the understanding of underlying causes of developmental disorders and cancer, according to a recent study.

Investigators from the laboratory of Ali Shilatifard, PhD, have developed a novel technique to precisely and efficiently study gene regulation, which may accelerate the development of new therapeutic strategies, according to a recent study published in Molecular Cell.

Northwestern University scientists have designed a new implantable device that can monitor fluctuating levels of proteins within the body in real time.

Northwestern Medicine scientists have discovered how a protein in a deadly type of lung cancer can control how the immune system responds to the tumor, according to a study published in the Proceedings of the National Academy of Sciences.

Investigators from the laboratory of Marc Mendillo, PhD, have discovered new cellular regulators of an established cancer cell transcription factor linked to cancer cell resilience and tumor progression, according to findings published in the Proceedings of the National Academy of Sciences.

Northwestern Medicine scientists have discovered increased immune cell activity in Merkel cell carcinoma tumors, which could help predict treatment response in patients and inform the development of new targeted therapies, according to findings published in the journal Cancer Discovery.

Inflamed heart muscles can mount immune responses even in the absence of immune cells, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

A multi-institutional team of investigators have developed a new framework for supporting healthcare providers in implementing polygenic risk score-based testing into primary care settings, according to a recent study published in Nature Medicine.

Northwestern Medicine investigators have discovered that inhibiting a chromatin remodeling complex associated with a particular gene in small-cell lung cancer cells may decrease cancer cell differentiation and tumor growth, according to findings published in Nature Communications.

Investigators led by Issam Ben-Sahra, PhD, have discovered how cellular metabolism fluctuates in response to changes in levels of pyrimidines, metabolites used by cells to make DNA and RNA, according to a recent study published in Science.

Investigators led by Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine, have discovered previously unknown protein interactions in the heart’s atrium that are critical for normal heart function, according to findings published in the Proceedings of the National Academy of Sciences.

Northwestern Medicine investigators have successfully localized novel molecular mechanisms behind a genetic mutation found in a wide range of cancers, which could serve as a biomarker for improving patient stratification and treatment, according to findings published in Proceedings of the National Academy of Sciences.

Investigators from the laboratory of Ali Shilatifard, PhD, have discovered a new repeat gene cluster sequence that is exclusively expressed in humans and non-human primates, according to findings published in Science Advances.