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Feb

25

Pharmacology Research Works-in-Progress: Chuyu Chen, Ph.D. and Eugene Wyatt, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Chuyu Chen, Ph.D.Postdoctoral Fellow, Dr. Loukia Parisiadou Laboratory “Parkinson’s Disease Related LRRK2 Regulates Striatal Intracellular Signaling Cascades” Mutations in LRRK2 represent a strong genetic risk for both hereditary and sporadic forms of Parkinson’s disease. Therefore, knowledge on LRRK2 function might be leveraged for therapeutic benefit. LRRK2 is significantly enriched in spiny projection neurons (SPN) in the dorsal striatum. This cellular expression pattern argues that LRRK2 mutations contribute to striatal pathophysiology in PD. Our previous findings demonstrate that LRRK2 regulates glutamatergic synaptic functions by directing PKA signaling in SPNs, whereas the LRRK2R1441C pathogenic mutation results in increased synaptic PKA activities. As PKA pathway is the critical effector of dopamine receptors, we showed that this aberrant PKA activity in LRRK2R1441C SPNs leads to perturbations in dopaminergic and corticostriatal signaling. We propose that altered subcellular compartmentalization of PKA imposed by the LRRK2R1441C mutation is the central mechanism for aberrant PKA signaling in SPNs. In the present study, using a series of super-resolution, structured illumination microscopy (SIM) imaging and PKA sensors we show how PKA localization shapes PKA activity in pathway-specific (direct and indirect) mutant LRRK2 SPNs. Specifically, we determine whether the effect of LRRK2 on PKA localization results in increased PKA availability to synaptic A-kinase anchoring protein 5 (AKAP5), suggesting a direct contribution of AKAP5 to LRRK2-related phenotypes. Overall, our study provides mechanistic insights of LRRK2-mediated cellular deficits in the striatum that in turn contributes to PD symptomatology. Eugene Wyatt, Ph.D.Research Assistant Professor of Pharmacology "Generating Mouse Models Through the Northwestern TTML" Genetically modified mice are essential research tools used to understand gene function and model disease. The advent of CRISPR gene editing technology has revolutionized the process of generating mouse models, reducing costs and improving efficiency. The Northwestern University Transgenic and Targeted Mutagenesis Laboratory (TTML) has extensive experience using the most cutting-edge CRISPR gene editing techniques to generate genetically modified mice. This includes knock-outs, point mutations, insertion of epitope tags, and conditional alleles. The TTML offers project design consultation, and can target mutations in embryos and embryonic stem cells. In addition, the TTML offers a comprehensive range of services for the Northwestern community.

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Feb

26

Microbiology-Immunology Department:Daniel Giraldo

Chicago - 12:00 PM - 1:00 PM

" Immunoregulatory Targeting of the Type 1 IFN Response Protects Against Mortality in a Murine Model of Neonatal HSV-1 Encephalitis" Speaker: Daniel Giraldo, Driskill Graduate Program, Lab of Richard Longnecker, PhD TOPIC Newborn infection with herpes simplex virus (HSV) is a serious, life-threatening condition with an incidence of 1 in 3,200 deliveries in the U.S. Unlike adult infections, which are commonly asymptomatic, over 50% of neonatal HSV infections result in disseminated disease or encephalitis. However, the nature of these age-dependent differences to HSV infection remains largely understudied. Here we explore how intrinsic differences in the type I IFN pathway in the central nervous system between the adult and the newborn correlate with increased susceptibility to HSV-1 infection and how this pathway can be modulated to provide protection to the newborn. Our studies will provide important insights into the mechanisms controlling age-dependent differences in the innate immune response to CNS injury throughout development and may lead to novel therapeutic approaches.

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Feb

28

BMG Seminar: Dissecting the molecular mechanisms and therapeutic vulnerabilities of mutant calreticulin in myeloproliferative neoplasms- Shannon Elf, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Shannon Elf, PhDAssistant Professor The University of Chicago   Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN). Our work has sought to dissect the molecular mechanism by which mutations in CALR function as phenotypic drivers in MPN pathogenesis, as well as to identify unique molecular vulnerabilities in CALR-mutated MPN cells. Our mechanistic studies have revealed the following key findings: i) mutant CALR binds to the thrombopoietin receptor (MPL) to activate JAK-STAT signaling and drive cellular transformation, thus rendering mutant CALR-transformed hematopoietic cells sensitive to JAK2 inhibition; ii) the oncogenicity of mutant CALR is dependent on the positive electrostatic charge of the mutant C-terminus, which is necessary for physical interaction between mutant CALR and MPL, and iii) mutant CALR binds directly to the extracellular domain of MPL via its N-glycosylation sites, and that the lectin-dependent function of CALR is required for this interaction. Together, this work has revealed important insight into the mechanism by which mutant CALR drives hematopoietic transformation in MPN. We next sought to exploit the insight gained through our mechanistic studies to identify new therapeutic targets in CALR-mutated MPN. Although CALR+ MPN patients experience reduced symptom burden in response to JAK inhibitor treatment, these agents have minimal disease-modifying activity and are not curative. This points to the importance of identifying novel targets for therapeutic intervention in CALR-mutated MPN. We performed RNA sequencing studies on cell lines expressing wild type CALR, mutant CALR, or JAK2 V617F, and found that the PERK-eIF2a-ATF4 axis of the unfolded protein response (UPR) is significantly up-regulated only in mutant CALR-expressing cells. Mechanistically, we found that activation of this pathway is due to loss of CALR chaperone activity in the mutant protein, and that the endoplasmic reticulum-associated degradation (ERAD) pathway, an ATF4 target and proteasomal degradation pathway, is up-regulated as a consequence. Accordingly, we found that inhibition of this pathway with the proteasome inhibitor bortezomib leads to increased cell death in mutant CALR-expressing cells, but not cells expressing wild type CALR or JAK2 V617F. This suggests that dependence on this UPR axis is specific to CALR-mutated cells. Together, our data suggests that the UPR may be exploited for therapeutic intervention in CALR-mutated MPN patients, either alone or in combination with JAK inhibition, with the hope of improving upon currently available therapies.

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Mar

01

"Mechanism of Rapid Antidepressant Action"

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Lisa Monteggia, Ph.D. Clinical studies have demonstrated that a single subpsychotomimetic dose of ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, produces rapid antidepressant responses in patients with major depressive disorder. Data will be presented showing that ketamine mediated blockade of NMDA receptors at rest targets a specific signaling cascade that involves deactivation of eukaryotic elongation factor 2 (eEF2) kinase, resulting in reduced eEF2 phosphorylation and desuppression of rapid dendritic protein translation, including BDNF, which then contributes to synaptic plasticity mechanisms. These findings identify critical determinants of how blocking spontaneous neurotransmission impacts synaptic plasticity with implications for ketamine mediated antidepressant responses.

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Mar

01

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Mar

05

Microbiology-Immunology Department: Katherine A. Radek, PhD

Chicago - 12:00 PM - 1:00 PM

"Cholinergic Regulation of Skin Antimicrobial Responses in Models of Injury and Infection" Speaker: Katherine A. Radek, PhD - Loyola University Chicago Host: Melissa Brown, PhD TOPIC The Radek laboratory focuses on how epidermal cholinergic signaling controls antimicrobial responses in the skin. The pathways by which skin antimicrobial responses are induced have been more thoroughly investigated, while those mechanisms which suppress them have not been fully elucidated. We established that activation of keratinocyte nicotinic acetylcholine receptors (nAChRs), specifically CHRNA7, dampens antimicrobial responses in several models of skin bacterial infection and wound healing. This suggests that CHRNA7 could be a novel target to boost skin antimicrobial responses as a means to improve infection and wound healing outcomes.

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Mar

07

BMG Seminar: Mitochondrial anchors: positioning mitochondria and more- Laura Lackner, PhD

Chicago - 9:00 AM - 10:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Laura Lackner, PhDAssistant Professor of Molecular BiosciencesNorthwestern University Weinberg College of Arts and Sciences   The Lackner lab is interested in the fundamental biological question of how spatial and dynamic organization within cells is achieved. As a model for intracellular organization, we study the mechanisms that position organelles. While once thought to operate independently, it is clear that organelles contact other organelles, and the positioning of organelles and the contacts they make play critical roles in a wide variety of cellular functions. The organelle that has been the primary focus of our research is the mitochondrion. By exploiting the strengths of the facile yeast system and a combination of cell biological, genetic, and biochemical approaches, we are addressing fundamental questions about the mechanisms used by cells to position mitochondria as well as form and regulate interorganelle contacts.

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Mar

07

Causal inference on pathophysiological mediators in psychiatry - Akira Sawa, MD, PhD

Chicago - 2:00 PM - 3:00 PM

The Center for Autism and Neurodevelopment of Northwestern University Feinberg School of Medicine welcomes you to attend a lecture featuring: Akira Sawa, MD, PhDDirector and Sachiko Kuno and Ryuji Ueno Innovation ProfessorJohns Hopkins Schizophrenia CenterJohns Hopkins University School of Medicine and Bloomberg School of Public Health Supported by technological advances and collaborative efforts, psychiatric genetics has provided robust genetic findings in the past decade, particularly through genome-wide association studies (GWASs). However, translating these genetic findings into biological mechanisms and new therapies has been enormously challenging because of the complexity of their interpretation. Furthermore, the heterogeneity among patients with the same diagnosis, such as schizophrenia or major depressive disorder, challenges the biological validity of existing categorical approaches, which is further complicated by the pleiotropic nature of many genetic variants across multiple disorders. Therefore, in the post-GWAS era, the greatest challenge lies in integrating such enriched genetic information with functional dimensions of neurobiological measures and observable behaviors. In this integration, the causal inference from genotypes to phenotypes through intermediate biological processes is of particular importance. This presentation aims to construct an intellectual framework in which we may obtain causal, mechanistic insights into how multifactorial etiologies, in particular many genetic variants, affect downstream biological pathways that lead to dimensions of psychiatric relevance. Akira Sawa, MD, PhD, is a physician scientist in psychiatry and neuroscience, who originally received an M.D. from the University of Tokyo, followed by clinical and research training in both Japan and the United States. He is currently the Director and Endowed Chair of the Johns Hopkins Schizophrenia Center in which he leads an academic model that integrates patient care, research, and outreach. His research interest is to elucidate molecular and circuitry mechanisms of frontal lobe-mediated, high-level brain function in conjunction with adolescent brain maturation.

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Mar

08

Department of Physiology Seminar Series - Amanda Law, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Amanda Law, Ph.D.

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Mar

08

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Mar

11

Genotypes to phenotypes: Lessons from the human genome and transcriptome - Barbara Stranger, PhD

Chicago - 2:00 PM - 3:00 PM

Barbara E. Stranger, PhDAssistant Professor, Department of Medicine, Section of Genetic MedicineCore Member, Institute for Genomics and Systems BiologyFellow, Center for Translational Data ScienceThe University of Chicago This talk will illustrate how knowledge of the human transcriptome can inform on genome function and complex trait variation. The lecture will include examples of the genetic basis of gene regulation, applications to immune-mediated phenotypes, and the effects of sex on transcriptional variation. Dr. Barbara Stranger is an Assistant Professor in the Department of Genetic Medicine at the University of Chicago. In addition, she is a Faculty Fellow in the Institute for Genomics and Systems Biology and The Center for Translational Data Science. Her lab analyzes multi-dimensional human genomics data, particularly transcriptome data and genetic variation data, in the context of health and disease. She develops effective analytic approaches for large-scale analysis of functional genomics data, and applies systems biology methodologies to integrate data of different types to inform biology of complex traits. She is a member of the Analysis Working Group (AWG) of NIH’s Genotype-Tissue Expression (GTEx) project, and leads the Sex Differences Working Group within the GTEx AWG. Current projects in her laboratory focus on understanding mechanisms and consequences of sexual dimorphism in: 1) Genetic regulation of gene expression in GTEx, 2) Genetic regulation of protein expression in GTEx, 3) Genetic architecture of neuropsychiatric traits, and 4) Genetics and genomics of cancer and response to therapy. She has a longstanding interest in evolution, and also applies the tools and approaches of population and evolutionary genetics to her research areas.  

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Mar

14

BMG Seminar: Brian Freeman, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Brian Freeman, PhDProfessor of Cell and Developmental BiologyUniversity of Illinois  

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Mar

15

Department of Physiology Seminar Series - Jeanne Paz, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Jeanne Paz, Ph.D.

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Mar

15

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Mar

15

How Advanced Genetics is Changing Our Lives - Steven Keiles, MS, LCGC

Chicago - 4:00 PM - 5:00 PM

Steven Keiles, MS, LCGCSr. Director, Genomic Services, Quest Diagnostics Session Overview: The goal of the session is to provide an overview of current advances in genetic discoveries and technologies. We will then review how these technological advancements are being put into practice in the form of consumer genetics and personalized medicine. We will also address the state of the payer market and how they are viewing such a rapidly advancing field. Learning Objectives:1. Describe how next generation sequencing has changed how we use genetic testing today.2. Discuss at least three clinical uses of new genetic technology3. Recall at least two requirements for payers to offer coverage of genetic testing. Bio: Steven is currently the Senior Director of Genomic Services at Quest Diagnostics where he oversees and manages all activities of the genetic counselors for Quest Diagnostics. In his role he acts as the liaison between Genomic Services and other areas of the company such as: Advanced Diagnostics, Corporate Medical, R&D, Laboratory Services, Finance, Legal, Compliance, and Commercial. He earned a master’s degree in genetic counseling from Sarah Lawrence College, a bachelor’s degree in psychology from Binghamton University in NY. Prior to joining Quest, Steven was with Ambry Genetics, which he joined in 2000 during that company’s start-up phase. His positions included Director of Genetic Specialists, Director of Clinical Affairs and Vice President of Clinical Diagnostics. Steven also has more than 20 years of clinical experience in pediatric, adult and prenatal genetic counseling, and was a recognized leader in the molecular diagnostics and phenotypic associations for Cystic Fibrosis and was a pioneer in helping bring hereditary cancer panels into the mainstream. He started his career working as a Clinical Genetic Counselor at Kaiser Permanente, Los Angeles, CA, where he was the primary genetic counselor for 17 years. Steven has also been active in the National Society of Genetic Counselors, chairing several committees and task forces, serving on its Board of Directors multiple times as well as having served as the president in 2009.  

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Mar

18

"An RNA-Centric View of Neurodevelopment: From Single Nucleotide Resolution Maps to Functions" - Chaolin Zhang, Ph.D.

Chicago - 4:00 PM - 5:00 PM

The Department of Pharmacology Seminar Series is pleased to welcome Dr. Chaolin Zhang. Chaolin Zhang, Ph.D.Assistant ProfessorDepartments of Systems Biology and Biochemistry & Molecular BiologyColumbia University Medical Center Abstract:Dr. Chaolin Zhang is an Assistant Professor in Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, and Motor Neuron Center at Columbia University since 2012. His lab uses an integrative approach to study neuronal RNA-binding proteins and how they regulate the transcriptomic diversity in the nervous system through alternative splicing in both normal and disease contexts. A current focus of the lab is to elucidate mechanisms underlying the precise timing of dynamic transcript isoform switches and the functional consequences during neural development. These works are done in model systems including in vitro neural differentiation from embryonic stem cells and mice. Dr. Zhang’s work has contributed to mapping protein-RNA interactions at single nucleotide resolution, to constructing neuronal RNA regulatory networks with high sensitivity and specificity, and to dissecting their function in neurodevelopment.

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Mar

21

BMG Seminar: Anthony G. Letai, MD, PHD

Chicago - 2:00 PM - 3:00 PM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Anthony G. Letai, MD, PHDProfessor of Medicine, Harvard Medical SchoolProfessor of Medicine, Hematologic Neoplasia/MalignanciesDana-Farber Cancer Institute  

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Mar

22

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Mar

25

Pharmacology Seminar: Indira M. Raman, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Indira M. Raman, Ph.D.Bill and Gayle Cook ProfessorDepartment of NeurobiologyWeinberg School of Arts & Sciences

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Mar

28

BMG Seminar: Heritable gene expression programs through space and time - Yoav Gilad, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Yoav Gilad, PhDProfessor and Chief, Section of Genetic Medicine, Department of MedicineProfessor of Human GeneticsThe University of Chicago  

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Mar

29

Department of Physiology Seminar Series - Massimo Scanziani, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Massimo Scanziani, Ph.D.

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Mar

29

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Apr

01

Joint Pharmacology & Seizure Focus Seminar: Alex Shcheglovitov, Ph.D.

Chicago - 12:00 PM - 1:00 PM

Joint Department of Pharmacology and Seizure Focus Forum Seminar Alex Shcheglovitov, Ph.D.Assistant Professor of Neurobiology & AnatomyAdjunct Assistant Professor of Psychiatry and BioengineeringUniversity of Utah    

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Apr

03

BMG Seminar: Lewis C. Cantley, PhD

Chicago - 4:00 PM - 5:00 PM

The Department of Biochemistry and Molecular Genetics Distinguished Seminar Series presents: Lewis C. Cantley, PhDMeyer Director Sandra and Edward Meyer Cancer Center at Weill Cornell Medical College Ronald P. Stanton Clinical Cancer Program at NewYork-PresbyterianProfessor of Cancer Biology in Medicine Weill Cornell Medical College  

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Apr

05

Department of Physiology Seminar Series - Peter Strickland, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Peter Strickland, Ph.D.

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Apr

05

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Apr

08

Pharmacology Seminar: Michelle Day, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Michelle Day, Ph.D.Research Associate ProfessorDepartment of PhysiologyFeinberg School of Medicine

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Apr

11

BMG Seminar: Shelby Blythe, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Shelby Blythe, PhDAssistant Professor of Molecular BiosciencesNorthwestern University Weinberg College of Arts and Sciences  

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Apr

12

Department of Physiology Seminar Series - Denise Cai, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Denise Cai, Ph.D.

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Apr

12

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Apr

15

Pharmacology Seminar: Randy D. Blakely, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Randy D. Blakely, Ph.D.Executive Director of FAU Brain InstituteProfessor of Biomedical ScienceFlorida Atlantic University

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Apr

18

BMG Seminar: Angelika Amon, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Angelika Amon, PhDInvestigator, Howard Hughes Medical InstituteKathleen and Curtis Marble Professor of Cancer ResearchDavid H. Koch Institute for Integrative Cancer Research Professor of BiologyMassachusetts Institute of Technology  

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Apr

18

CMB Seminar: Drosophila to Model Nucleolar Stress

Chicago - 3:30 PM - 4:30 PM

Please join the Department of Cell and Molecular Biology, Feinberg School of Medicine, in welcoming Patrick J. DiMario PhD, Professor, Biochemistry and Molecular Biology (BMB) and Cellular, Developmental & Integrative Biology (CDIB), College of Science, Lousiana State University, Baton Rouge, for his presentation about  "Drosophila to Model Nucleolar Stress".   His CMB faculty host is Associate Professor Sui Huang.

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Apr

19

Department of Physiology Seminar Series - Zachary Knight, Ph.D.

No Location - 12:00 PM - 1:00 PM

The department of Physiology welcomes Zachary Knight, Ph.D.

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Apr

19

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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Apr

22

Julius B. Kahn Lecture: Mark Von Zastrow, M.D., Ph.D.

Chicago - 4:00 PM - 5:00 PM

The Department of Pharmacology is pleased to present a special seminar by the nominated Julius B. Kahn Visiting Professor. Mark Von Zastrow, M.D., Ph.D.Professor of Psychiatry University of California San Francisco  

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Apr

25

BMG Seminar: Brian Kelch, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Brian Kelch, PhDAssistant Professor of Biochemistry and Molecular PharmacologyUniversity of Massachusetts Medical School  

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Apr

26

BMG Journal Club

No Location - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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Apr

29

Pharmacology Seminar: Jean Ju Chung, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Jean Ju Chung, Ph.D.Assistant Professor of Cellular & Molecular PhysiologyYale School of Medicine

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Apr

30

Microbiology-Immunology Department: Lubov Grigoryeva

Chicago - 12:00 PM - 1:00 PM

"Endosomal TLRs are Major Pathways to Recognizing Legionella pneumophila in Human Macrophages" Speaker: Lubov Grigoryeva, Driskill Graduate Program, Lab of Nicholas Cianciotto, PhD TOPIC Legionella pneumophila is a gram-negative bacterium that causes a severe form of pneumonia known as Legionnaire’s disease. Preliminary data from our laboratory revealed that the recognition of wild-type L. pneumophila by human macrophages deviates from previously reported pathways in murine macrophages, calling into question the field’s reliance on murine-based experimentation. My project seeks to understand the mechanisms of innate immune signaling in human macrophages after Lp infection.

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May

02

BMG Seminar: Jared Rutter, PhD

No Location - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Jared Rutter, PhDInvestigator, Howard Hughes Medical InstituteProfessor of BiochemistryUniversity of Utah School of Medicine  

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May

03

Department of Physiology Seminar Series - Francis S. Lee, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Francis S. Lee, Ph.D.

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May

03

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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May

06

Pharmacology Seminar: Thomas Hnasko, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Thomas Hnasko, Ph.D.Assistant Professor of NeurosciencesUC San Diego

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May

09

BMG Seminar: Yong Wan, PhD

Chicago - 10:00 AM - 11:00 AM

The Department of Biochemistry and Molecular Genetics Departmental Seminar Series presents: Yong Wan, PhDProfessor of Obstetrics and Gynecology (Reproductive Science in Medicine) and PharmacologyNorthwestern University Feinberg School of Medicine  

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May

09

DNA Technologies to Improve Diagnosis and Treatment of Autism Spectrum Disorders - Jonathan Sebat, PhD

Chicago - 2:00 PM - 3:00 PM

The Center for Autism and Neurodevelopment of Northwestern University Feinberg School of Medicine welcomes you to attend a lecture featuring: Jonathan Sebat, PhDDirector, Beyster Center for Genomics of Psychiatric DiseaseProfessor of Psychiatry, Cellular and Molecular Medicine, and PediatricsInstitute for Genomic MedicineUniversity of California, San Diego Dr Jonathan Sebat is a leader in the field of psychiatric genetics, and an expert in the genomic characterization of autism by Whole Genome Sequencing (WGS). His research has made substantial contributions to our current knowledge of genome-wide patterns of germline mutation and the contribution of rare and de novo genetic variants to risk for common disease. His early research on patterns of structural genetic variation (SV) in the human genome led the initial discovery of the widespread abundance of SV in the human genome. Application of SV detection methods to neuropsychiatric disorders, including autism spectrum disorders and schizophrenia has served to elucidate the role of rare structural variants in neuropsychiatric disorders. Dr. Sebat is the Director of the Beyster Center for Psychiatric Genomics, where he leads an interdisciplinary team in the clinical and genomic analysis of patient cohorts at UCSD and Rady Children’s Hospital. In addition, he has led multiple large consortium efforts including as chair of the CNV analysis group for the Psychiatric Genomics Consortium and a co-lead investigator on the Human Genome Structural Variation Consortium (HGSVC) where his group has led interdisciplinary teams on the analysis of genomic and clinical datasets on large cohorts.

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May

10

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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May

13

Pharmacology Seminar: Lucas Pozzo-Miller, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Lucas Pozzo-Miller, Ph.D.Professor, Department of NeurobiologyAssociate Director, Comprehensive Neuroscience CenterCo-Director, Neuroscience Graduate Theme, Graduate Biomedical ScienceUniversity of Alabama at Birminghim School of Medicine

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May

16

Center for Autism and Neurodevelopment seminar - Daniel Geschwind, MD, PhD

Chicago - 2:00 PM - 3:00 PM

The Center for Autism and Neurodevelopment of Northwestern University Feinberg School of Medicine welcomes you to attend a lecture featuring: Daniel Geschwind, MD, PhD Gordon and Virginia MacDonald Distinguished Chair in Human GeneticsProfessor of Neurology, Psychiatry, and Human GeneticsDirector, Department of Neurology Program in NeurogeneticsDirector, Center for Autism Research and Treatment (CART) Co-director, Center for Neurobehavioral GeneticsSenior Associate Dean and Associate Vice Chancellor, Institute for Precision HealthDavid Geffen School of Medicine at UCLA

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May

17

Department of Physiology Seminar Series - Moshe Szyf, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Moshe Szyf, Ph.D.

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May

17

Simpson Querrey Center for Epigenetics Forum on Biochemistry, Epigenetics, and Metabolism (BEaM)

Chicago - 3:30 PM - 5:00 PM

The BEAM Forum is a data group where Simpson Querrey Epigenetics Center members present ongoing work being conducted in the Center. It is a great opportunity to get feedback on your work from colleagues, and to make new connections and foster new collaborations within the Center. The forum is normally held every other Friday from 3:30-5:00 pm throughout the year in Baldwin Auditorium. Two presenters will give ~30 minute talks each week with 10 minutes for discussion and questions. We invite all labs associated with the SQE Center to participate. We welcome presentation from students, techs, postdocs, and PIs. Presenting work-in-progress is always encouraged! Pizza and soda is provided.

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May

20

Department of Physiology Seminar Series - Shari Wiseman, Ph.D.

Chicago - 12:00 PM - 1:00 PM

The department of Physiology welcomes Shari Wisemann, Ph.D.

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May

20

Pharmacology Seminar: Richard H. Kramer, Ph.D.

Chicago - 4:00 PM - 5:00 PM

Richard H. Kramer, Ph.D.Professor of Neurobiology and Vision ScienceCH and Annie Li Chair in Molecular Biology of DiseasesUniversity of California, Berkeley

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May

22

SQE Invited Lecturer: Michael Green, MD/PhD

Chicago - 10:00 AM - 11:00 AM

The Simpson Querrey Center for Epigenetics presents: Michael Green, MD/PhDDepartment Chair, Molecular, Cell and Cancer BiologyUniversity of Massachusetts Medical SchoolWorcester, MA  

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May

24

BMG Journal Club

Chicago - 3:30 PM - 5:00 PM

The BMG Journal Club will convene every other Friday from 3:30pm to 5:00pm. This is an opportunity for the department to come together and have in-depth discussions about the current literature and the overall implications of new studies, enhancing everyone’s knowledge of the field at large and about each other’s research interests within the department; providing possible opportunities to collaborate as well. This is also an opportunity to practice vital presentation skills in front of a friendly audience. Pizza and soda will be served.

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