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Northwestern University Feinberg School of Medicine
Institute for Artificial Intelligence in Medicine

Publications

Browse the list below to see the latest scientific publications stemming from our institute faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

  1. Gerratana L, Davis AA, Foffano L, Reduzzi C, Rossi T, Medford A, Clifton K, Shah AN, Bucheit L, Velimirovic M  et al.  Integrating machine learning-predicted circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in metastatic breast cancer: A proof of principle study on endocrine resistance profiling.  Cancer Lett  2025 Jan 28;609:217325. doi:10.1016/j.canlet.2024.217325
  2. Shimbo D, Shah RU, Abdalla M, Agarwal R, Ahmad FS, Anaya G, Attia ZI, Bull S, Chang AR, Commodore-Mensah Y  et al.  Transforming Hypertension Diagnosis and Management in The Era of Artificial Intelligence: A 2023 National Heart, Lung, and Blood Institute (NHLBI) Workshop Report.  Hypertension  2025 Jan;82(1):36-45. doi:10.1161/HYPERTENSIONAHA.124.22095
  3. Luo Y, Fraser L, Jezykowski J, Gupta NA, Miethke AG, Taylor SA, Alonso EM, Horslen S, Kohli R, Molleston JP  et al.  Interleukin 8-CXCR2 mediated neutrophil extracellular trap (NET) formation in biliary atresia associated with NET-Induced stellate cell activation.  Hepatology  2024 Dec 18;. doi:10.1097/HEP.0000000000001195
  4. Zamani P, Shah SJ, Cohen JB, Zhao M, Yang W, Afable JL, Caturla M, Maynard H, Pourmussa B, Demastus C  et al.  Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.  JAMA Cardiol  2024 Dec 18;. doi:10.1001/jamacardio.2024.4417
  5. Shin J, Luo Y  Relationship between exposure to multiple heavy metals and depressive symptoms in the US: The impact of alcohol consumption.  Heliyon  2024 Dec 15;10(23):e40221. pii:e40221
  6. Michelson KN, Fishman AC, Feinberg EC, Ross S, Wald HS, Auerbach C, Roth S  Antisemitism in American Healthcare: A Survey Study of Reported Experiences.  J Gen Intern Med  2024 Dec 11;. doi:10.1007/s11606-024-09159-x
  7. Stefanopoulos L, Kim BW, Sheppard J, Azcona EA, Vike NL, Bari S, Lalvani S, Woodward S, Maglaveras N, Block M  et al.  Discrete, recurrent, and scalable patterns in non-operant judgement underlie affective picture ratings.  Cogn Process  2024 Dec 07;. doi:10.1007/s10339-024-01250-9
  8. Butt JH, Henderson AD, Jhund PS, Claggett BL, Desai AS, Lay-Flurrie J, Viswanathan P, Lage A, Scheerer MF, Lam CSP  et al.  Finerenone, Obesity, and Heart Failure With Mildly Reduced/Preserved Ejection Fraction: Prespecified Analysis of FINEARTS-HF.  J Am Coll Cardiol  2024 Dec 04;. pii:S0735-1097(24)10423-8
  9. Wang MC, Awoyemi T, Allen NB, Shah R, Nayor M, Luo Y, Lima JAC, Lloyd-Jones DM, Khan SS  Latent class analysis of cardiac structure and function and association with premature cardiovascular disease: The Coronary Artery Risk Development in Young Adults (CARDIA) study.  Am J Prev Cardiol  2024 Dec;20:100889. pii:100889
  10. Vaduganathan M, Filippatos G, Claggett BL, Desai AS, Jhund PS, Henderson A, Brinker M, Kolkhof P, Schloemer P, Lay-Flurrie J  et al.  Author Correction: Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes.  Nat Med  2024 Dec;30(12):3778. doi:10.1038/s41591-024-03372-1
  11. Fudim M, Borlaug BA, Mohan RC, Price MJ, Fail P, Goyal P, Hummel SL, Zirakashvili T, Shaburishvili T, Patel RB  et al.  Endovascular Ablation of the Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: The REBALANCE-HF Randomized Clinical Trial.  JAMA Cardiol  2024 Dec 01;9(12):1143-1153. doi:10.1001/jamacardio.2024.2612
  12. Haynes G, Muhammad F, Weber KA, Khan AF, Hameed S, Shakir H, Van Hal M, Dickson D, Rohan M, Dhaher Y  et al.  Tract-specific magnetization transfer ratio provides insights into the severity of degenerative cervical myelopathy.  Spinal Cord  2024 Dec;62(12):700-707. doi:10.1038/s41393-024-01036-y
  13. Vaduganathan M, Filippatos G, Claggett BL, Desai AS, Jhund PS, Henderson A, Brinker M, Kolkhof P, Schloemer P, Lay-Flurrie J  et al.  Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes.  Nat Med  2024 Dec;30(12):3758-3764. doi:10.1038/s41591-024-03264-4
  14. Gao J, Giro P, Delaney JA, Rasmussen-Torvik L, Taylor KD, Thorp EB, Doyle MF, Feinstein MJ, Sitlani CM, Olson N  et al.  Immune cell profiling of the ICAM1 p.K56M heart failure with preserved ejection fraction risk variant.  ESC Heart Fail  2024 Dec;11(6):4427-4431. doi:10.1002/ehf2.14983
  15. Cicek V, Cikirikci EHK, Babaoğlu M, Erdem A, Tur Y, Mohamed MI, Cinar T, Savas H, Bagci U  Machine learning for prognostic prediction in coronary artery disease with SPECT data: a systematic review and meta-analysis.  EJNMMI Res  2024 Nov 26;14(1):117. pii:117
  16. Karp JF, Brinton RD, Fournier JC, Harding L, Jha MK, Lenze EJ, Mathew SJ, Meltzer-Brody S, Mohr DC, Riva-Posse P  et al.  Difficult to Treat Depression: Focus on Approach, Algorithms, and Access.  J Clin Psychiatry  2024 Nov 25;85(4). pii:psprmdd2408ah
  17. Ostrominski JW, Højbjerg Lassen MC, Claggett BL, Miao ZM, Inzucchi SE, Docherty KF, Desai AS, Jhund PS, Køber L, Ponikowski P  et al.  Sodium-glucose co-transporter 2 inhibitors and new-onset diabetes in cardiovascular or kidney disease.  Eur Heart J  2024 Nov 21;. pii:ehae780
  18. Fejzo M, Wang X, Zöllner J, Pujol-Gualdo N, Laisk T, , Finer S, van Heel DA, , Brumpton B  et al.  Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.  medRxiv  2024 Nov 20;. pii:2024.11.19.24317559
  19. Stiles-Shields C, Reyes KM, Lakhtakia T, Smith SR, Barnas OE, Gray EL, Krause CJ, Kruzan KP, Kwasny MJ, Mir Z  et al.  A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial.  BMC Psychiatry  2024 Nov 19;24(1):828. pii:828
  20. Cai W, Liu X, Barajas S, Xiao S, Vemula S, Chen H, Yang Y, Bochers C, Henley D, Liu S  et al.  Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes.  Leukemia  2024 Nov 19;. doi:10.1038/s41375-024-02462-w
  21. Simon G, Moise N, Mohr DC  Management of Depression-Reply.  JAMA  2024 Nov 19;332(19):1674-1675. doi:10.1001/jama.2024.18405
  22. Vardeny O, Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F  et al.  Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.  JAMA Cardiol  2024 Nov 17;. pii:e244539
  23. Hanafiah A, Geng Z, Liu T, Tai YT, Cai W, Wang Q, Christensen N, Liu Y, Yue F, Gao Z  PRC1 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation.  bioRxiv  2024 Nov 15;. pii:2024.11.13.623456
  24. Adler DA, Yang Y, Viranda T, Xu X, Mohr DC, VAN Meter AR, Tartaglia JC, Jacobson NC, Wang F, Estrin D  et al.  Beyond Detection: Towards Actionable Sensing Research in Clinical Mental Healthcare.  Proc ACM Interact Mob Wearable Ubiquitous Technol  2024 Nov;8(4). pii:160
  25. Selvaraj S, Patel S, Sauer AJ, McGarrah RW, Jones P, Kwee LC, Windsor SL, Ilkayeva O, Muehlbauer MJ, Newgard CB  et al.  Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction.  Circ Heart Fail  2024 Nov;17(11):e011980. doi:10.1161/CIRCHEARTFAILURE.124.011980
  26. Chimura M, Petrie MC, Schou M, Martinez FA, Henderson AD, Claggett BL, Desai AS, Kolkhof P, Viswanathan P, Lage A  et al.  Finerenone Improves Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction Irrespective of Age: A Prespecified Analysis of FINEARTS-HF.  Circ Heart Fail  2024 Nov;17(11):e012437. doi:10.1161/CIRCHEARTFAILURE.124.012437
  27. Wu Y, Iorga M, Badhe S, Zhang J, Cantrell DR, Tanhehco EJ, Szrama N, Naidech AM, Drakopoulos M, Hasan ST  et al.  Precise Image-level Localization of Intracranial Hemorrhage on Head CT Scans with Deep Learning Models Trained on Study-level Labels.  Radiol Artif Intell  2024 Nov;6(6):e230296. pii:e230296
  28. Kim M, Wang X, Li Y, Lin Z, Collins CP, Liu Y, Ahn Y, Tsal HM, Song JW, Duan C  et al.  Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration.  Bioact Mater  2024 Nov;41:427-439. doi:10.1016/j.bioactmat.2024.07.029
  29. Doiron JE, Xia H, Yu X, Nevins AR, LaPenna KB, Sharp TE, Goodchild TT, Allerton TD, Elgazzaz M, Lazartigues E  et al.  Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.  Br J Pharmacol  2024 Nov;181(21):4294-4310. doi:10.1111/bph.16493
  30. Hasjim BJ, Harris A, Balbale SN, Obayemi JE, Beestrum M, Polineni P, Paukner M, Mohammadi M, Dentici OC, Kershaw KN  et al.  Social Disadvantage and Disparities in Chronic Liver Disease: A Systematic Review.  Am J Gastroenterol  2024 Oct 30;. doi:10.14309/ajg.0000000000003171
  31. , Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N  et al.  An integrated view of the structure and function of the human 4D nucleome.  bioRxiv  2024 Oct 27;. pii:2024.09.17.613111
  32. Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M  et al.  Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.  N Engl J Med  2024 Oct 24;391(16):1475-1485. doi:10.1056/NEJMoa2407107
  33. Mc Causland FR, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Henderson AD, Brinker M, Perkins R, Scheerer MF  et al.  Finerenone and Kidney Outcomes in Patients with Heart Failure: The FINEARTS-HF Trial.  J Am Coll Cardiol  2024 Oct 22;. pii:S0735-1097(24)10252-5
  34. Solomon SD, Ostrominski JW, Wang X, Shah SJ, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Verma S, Abildstrøm SZ  et al.  Effect of Semaglutide on Cardiac Structure and Function in Patients With Obesity-Related Heart Failure.  J Am Coll Cardiol  2024 Oct 22;84(17):1587-1602. doi:10.1016/j.jacc.2024.08.021
  35. Verma S, Butler J, Borlaug BA, Davies MJ, Kitzman DW, Petrie MC, Shah SJ, Jensen TJ, Rasmussen S, Rönnbäck C  et al.  Atrial Fibrillation and Semaglutide Effects in Obesity-Related Heart Failure With Preserved Ejection Fraction: STEP-HFpEF Program.  J Am Coll Cardiol  2024 Oct 22;84(17):1603-1614. doi:10.1016/j.jacc.2024.08.023
  36. Verma S, Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Rönnbäck C, Abildstrøm SZ, Liisberg K  et al.  Inflammation in Obesity-Related HFpEF: The STEP-HFpEF Program.  J Am Coll Cardiol  2024 Oct 22;84(17):1646-1662. doi:10.1016/j.jacc.2024.08.028
  37. Hasjim BJ, Mohammadi M, Balbale SN, Paukner M, Banea T, Shi H, Furmanchuk A, VanWagner LB, Zhao L, Duarte-Rojo A  et al.  High Hospitalization Rates and Risk Factors Among Frail Patients With Cirrhosis: A 10-year Population-based Cohort Study.  Clin Gastroenterol Hepatol  2024 Oct 18;. pii:S1542-3565(24)00903-0
  38. Nargesi AA, Adejumo P, Dhingra LS, Rosand B, Hengartner A, Coppi A, Benigeri S, Sen S, Ahmad T, Nadkarni GN  et al.  Automated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing.  JACC Heart Fail  2024 Oct 09;. pii:S2213-1779(24)00618-8
  39. Ozyoruk KB, Harmon SA, Lay NS, Yilmaz EC, Bagci U, Citrin DE, Wood BJ, Pinto PA, Choyke PL, Turkbey B  AI-ADC: Channel and Spatial Attention-Based Contrastive Learning to Generate ADC Maps from T2W MRI for Prostate Cancer Detection.  J Pers Med  2024 Oct 09;14(10). pii:1047
  40. Goldstein JA, Nateghi R, Cooper LAD  Machine Learning Assessment of Gestational Age in Accelerated Maturation, Delayed Maturation, Villous Edema, Chorangiosis, and Intrauterine Fetal Demise.  Arch Pathol Lab Med  2024 Oct 07;. doi:10.5858/arpa.2024-0274-OA
  41. Zhou T, Zhang B, Zhang D, Wu Q, Chen J, Li L, Lu Y, Becich MJ, Blecker S, Chilukuri N  et al.  Body Mass Index and Postacute Sequelae of SARS-CoV-2 Infection in Children and Young Adults.  JAMA Netw Open  2024 Oct 01;7(10):e2441970. pii:e2441970
  42. Dey S, Kurbanzade AK, Gel ES, Mihaljevic J, Mehrotra S  Optimization Modeling for Pandemic Vaccine Supply Chain Management: A Review and Future Research Opportunities.  Nav Res Logist  2024 Oct;71(7):976-1016. doi:10.1002/nav.22181
  43. Chaudhury AS, Ige M, Marwah S, Zhou X, Andrews CA, Kanwar K, Evans CT, Kho AN, Stein JD, Bryar PJ  et al.  Race, Social Determinants of Health, and the Quality of Diabetic Eye Care.  JAMA Ophthalmol  2024 Oct 01;142(10):961-970. doi:10.1001/jamaophthalmol.2024.3528
  44. Docherty KF, Buendia Lopez R, Folkvaljon F, de Boer RA, Cowie MR, Hammarstedt A, Kitzman DW, Kosiborod MN, Langkilde AM, Reicher B  et al.  Effect of Dapagliflozin on Accelerometer-Based Measures of Physical Activity in Patients With Heart Failure: An Analysis of the DETERMINE Trials.  Circ Heart Fail  2024 Oct;17(10):e012349. doi:10.1161/CIRCHEARTFAILURE.124.012349
  45. Kitzman DW, Voors AA, Mentz RJ, Lewis GD, Perl S, Myte R, Kaguthi G, Sjöström CD, Källgren C, Shah SJ  Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection Fraction: The AMETHYST Randomized Clinical Trial.  JAMA Cardiol  2024 Oct 01;9(10):892-900. doi:10.1001/jamacardio.2024.2435
  46. Shah SJ, Rigolli M, Javidialsaadi A, Patel RB, Khadra S, Goyal P, Little S, Wever-Pinzon O, Owens AT, Skali H  et al.  Cardiac Myosin Inhibition in Heart Failure With Normal and Supranormal Ejection Fraction: Primary Results of the EMBARK-HFpEF Trial.  JAMA Cardiol  2024 Sep 30;. doi:10.1001/jamacardio.2024.3810
  47. Yang M, Henderson AD, Talebi A, Atherton JJ, Chiang CE, Chopra V, Comin-Colet J, Kosiborod MN, Kerr Saraiva JF, Claggett BL  et al.  Effect of Finerenone on the KCCQ in Patients With HFmrEF/HFpEF: A Prespecified Analysis of FINEARTS-HF.  J Am Coll Cardiol  2024 Sep 29;. pii:S0735-1097(24)08532-2
  48. Docherty KF, Henderson AD, Jhund PS, Claggett BL, Desai AS, Mueller K, Viswanathan P, Scalise A, Lam CSP, Senni M  et al.  Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure with Mildly Reduced and Preserved Ejection Fraction: a Prespecified Analysis of The FINEARTS-HF Trial.  Circulation  2024 Sep 29;. doi:10.1161/CIRCULATIONAHA.124.072011
  49. Adekkanattu P, Furmanchuk A, Wu Y, Pathak A, Patra BG, Bost S, Morrow D, Wang GH, Yang Y, Forrest NJ  et al.  Deep learning for identifying personal and family history of suicidal thoughts and behaviors from EHRs.  NPJ Digit Med  2024 Sep 28;7(1):260. pii:260
  50. Vaduganathan M, Claggett BL, Kulac IJ, Miao ZM, Desai AS, Jhund PS, Henderson AD, Brinker M, Lay-Flurrie J, Viswanathan P  et al.  Effects of the Non-Steroidal MRA Finerenone with and without Concomitant SGLT2 Inhibitor Use in Heart Failure.  Circulation  2024 Sep 28;. doi:10.1161/CIRCULATIONAHA.124.072055