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Northwestern University Feinberg School of Medicine
Institute for Artificial Intelligence in Medicine

Publications

Browse the list below to see the latest scientific publications stemming from our institute faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

  1. Giuffrida AS, Sheriff S, Huang V, Weinberg BD, Cooper LAD, Liu Y, Soher BJ, Treadway M, Maudsley AA, Shim H  NNFit: A Self-Supervised Deep Learning Method for Accelerated Quantification of High-Resolution Short-Echo-Time MR Spectroscopy Datasets.  Radiol Artif Intell  2025 Mar;7(2):e230579. doi:10.1148/ryai.230579
  2. Quiriarte H, Cho E, Kim Y, Doiron JE, Davis G, Stampley J, Noland RC, Li Z, Shah SJ, Irving BA  et al.  Impact of Voluntary Exercise on Systemic Inflammation in a 2? Hit Model of Heart Failure With Preserved Ejection Fraction.  J Am Heart Assoc  2025 Feb 18;14(4):e038789. doi:10.1161/JAHA.124.038789
  3. Luo Y, Li Y, Ogunyemi O, Koski E, Himes BE  Leveraging large language models for academic conference organization.  NPJ Digit Med  2025 Feb 14;8(1):101. pii:101
  4. Mohammadi M, Hasjim BJ, Balbale SN, Polineni P, Huang AA, Paukner M, Banea T, Dentici O, Vitello DJ, Obayemi JE  et al.  Disease trajectory and competing risks of patients with cirrhosis in the US.  PLoS One  2025;20(2):e0313152. pii:e0313152
  5. Braumann S, Macherey-Meyer S, Polzin A, Costard-Jäckle A, Morbach C, Haring B, Lapp H, Ten Cate V, Gieswinkel A, Weliwitage J  et al.  MYSTERY-HF - Myeloperoxidase Inhibition in Patients With Heart Failure and Reduced Ejection Fraction - a Phase II Randomized Controlled Trial.  Circulation  2025 Feb 12;. doi:10.1161/CIRCULATIONAHA.125.074085
  6. Raeisi Dehkordi S, Wong IT, Ni J, Luebeck J, Zhu K, Prasad G, Krockenberger L, Xu G, Chowdhury B, Rajkumar U  et al.  Breakage fusion bridge cycles drive high oncogene number with moderate intratumoural heterogeneity.  Nat Commun  2025 Feb 10;16(1):1497. pii:1497
  7. Lyu H, Chen X, Cheng Y, Zhang T, Wang P, Wong JH, Wang J, Stasiak L, Sun L, Yang G  et al.  Pioneer factor GATA6 promotes colorectal cancer through 3D genome regulation.  Sci Adv  2025 Feb 07;11(6):eads4985. pii:eads4985
  8. Liu H, Abedini A, Ha E, Ma Z, Sheng X, Dumoulin B, Qiu C, Aranyi T, Li S, Dittrich N  et al.  Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants.  Science  2025 Feb 07;387(6734):eadp4753. doi:10.1126/science.adp4753
  9. Culler K, Zelnick LR, Mehta RC, de Sosa GR, Kansal M, Rao PS, Bhat Z, Taliercio J, Horwitz E, Chen J  et al.  The ICAM1 p.K56M variant and risk of heart failure in chronic kidney disease: the Chronic Renal Insufficiency Cohort study.  Heart  2025 Feb 06;. pii:heartjnl-2024-325205
  10. Jakubek YA, Ma X, Stilp AM, Yu F, Bacon J, Wong JW, Aguet F, Ardlie K, Arnett DK, Barnes K  et al.  Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood.  Am J Hum Genet  2025 Feb 06;112(2):276-290. doi:10.1016/j.ajhg.2024.12.014
  11. Gundogdu B, Chatterjee A, Medved M, Bagci U, Karczmar GS, Oto A  Physics-Informed Autoencoder for Prostate Tissue Microstructure Profiling with Hybrid Multidimensional MRI.  Radiol Artif Intell  2025 Feb 05;:e240167. doi:10.1148/ryai.240167
  12. Zhang D, Stein R, Lu Y, Zhou T, Lei Y, Li L, Chen J, Arnold J, Becich MJ, Chrischilles EA  et al.  Pediatric Gastrointestinal Tract Outcomes During the Postacute Phase of COVID-19.  JAMA Netw Open  2025 Feb 03;8(2):e2458366. pii:e2458366
  13. Adli M, Przybyla L, Burdett T, Burridge PW, Cacheiro P, Chang HY, Engreitz JM, Gilbert LA, Greenleaf WJ, Hsu L  et al.  MorPhiC Consortium: towards functional characterization of all human genes.  Nature  2025 Feb;638(8050):351-359. doi:10.1038/s41586-024-08243-w
  14. Butt JH, Jhund PS, Henderson AD, Claggett BL, Desai AS, Viswanathan P, Kolkhof P, Schloemer P, Amarante F, Lam CSP  et al.  Finerenone and new-onset diabetes in heart failure: a prespecified analysis of the FINEARTS-HF trial.  Lancet Diabetes Endocrinol  2025 Feb;13(2):107-118. doi:10.1016/S2213-8587(24)00309-7
  15. Bannon J, Smith JD, Van Ryzin MJ, McHugh M, Heinrich J, Walunas TL, Kho AN  Design of INSPIRE: Evaluation of the effectiveness of practice facilitation on implementation of screening, brief interventions, referral to treatment and medication for unhealthy alcohol use identification and treatment in primary care.  Contemp Clin Trials Commun  2025 Feb;43:101413. pii:101413
  16. Cai W, Liu X, Barajas S, Xiao S, Vemula S, Chen H, Yang Y, Bochers C, Henley D, Liu S  et al.  Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes.  Leukemia  2025 Feb;39(2):296-307. doi:10.1038/s41375-024-02462-w
  17. Shah SJ, Rigolli M, Javidialsaadi A, Patel RB, Khadra S, Goyal P, Little S, Wever-Pinzon O, Owens AT, Skali H  et al.  Cardiac Myosin Inhibition in Heart Failure With Normal and Supranormal Ejection Fraction: Primary Results of the EMBARK-HFpEF Trial.  JAMA Cardiol  2025 Feb 01;10(2):170-175. doi:10.1001/jamacardio.2024.3810
  18. Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B  et al.  Estimated Long-Term Benefits of Finerenone in Heart Failure: A Prespecified Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial.  JAMA Cardiol  2025 Feb 01;10(2):176-181. doi:10.1001/jamacardio.2024.3782
  19. Peterson TE, Lima JAC, Shah SJ, Bluemke DA, Bertoni AG, Liu Y, Ngo D, Varadarajan V, Mychaleckyj JC, Johnson CW  et al.  Proteomics of left ventricular structure in the Multi-Ethnic Study of Atherosclerosis.  ESC Heart Fail  2025 Feb;12(1):239-249. doi:10.1002/ehf2.15073
  20. Friedewald SM, Sieniek M, Jansen S, Mahvar F, Kohlberger T, Schacht D, Bhole S, Gupta D, Prabhakara S, McKinney SM  et al.  Triaging mammography with artificial intelligence: an implementation study.  Breast Cancer Res Treat  2025 Jan 29;. doi:10.1007/s10549-025-07616-7
  21. Koh J, Caron S, Watters AN, Vaidyanathan M, Melnick D, Santi A, Hudson K, Arguelles C, Mathur P, Etemadi M  Technological Adjuncts to Streamline Patient Recruitment, Informed Consent, and Data Management Processes in Clinical Research: Observational Study.  JMIR Form Res  2025 Jan 29;9:e58628. pii:e58628
  22. Gerratana L, Davis AA, Foffano L, Reduzzi C, Rossi T, Medford A, Clifton K, Shah AN, Bucheit L, Velimirovic M  et al.  Integrating machine learning-predicted circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in metastatic breast cancer: A proof of principle study on endocrine resistance profiling.  Cancer Lett  2025 Jan 28;609:217325. doi:10.1016/j.canlet.2024.217325
  23. Giuffrida AS, Ramesh K, Sheriff S, Maudsley AA, Weinberg BD, Cooper LAD, Shim H  An Accelerated Spectroscopic MRI Metabolite Quantification Based on a Deep Learning Method for Radiation Therapy Planning in Brain Tumor Patients.  Cancers (Basel)  2025 Jan 27;17(3). pii:423
  24. Li EV, Ren Y, Griffin J, Han C, Yamashita R, Mitani A, Zhou R, Huang HC, Yang X, Feng FY  et al.  An Artificial Intelligence-Digital Pathology Algorithm Predicts Survival After Radical Prostatectomy From the Prostate, Lung, Colorectal, and Ovarian Cancer Trial.  J Urol  2025 Jan 22;:101097JU0000000000004435. doi:10.1097/JU.0000000000004435
  25. Butt JH, Henderson AD, Jhund PS, Claggett BL, Desai AS, Lay-Flurrie J, Viswanathan P, Lage A, Scheerer MF, Lam CSP  et al.  Finerenone, Obesity, and Heart Failure With Mildly Reduced/Preserved Ejection Fraction: Prespecified Analysis of FINEARTS-HF.  J Am Coll Cardiol  2025 Jan 21;85(2):140-155. doi:10.1016/j.jacc.2024.10.111
  26. Yang M, Henderson AD, Talebi A, Atherton JJ, Chiang CE, Chopra V, Comin-Colet J, Kosiborod MN, Kerr Saraiva JF, Claggett BL  et al.  Effect of Finerenone on the KCCQ in Patients With HFmrEF/HFpEF: A Prespecified Analysis of FINEARTS-HF.  J Am Coll Cardiol  2025 Jan 21;85(2):120-136. doi:10.1016/j.jacc.2024.09.023
  27. Mc Causland FR, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Henderson AD, Brinker M, Perkins R, Scheerer MF  et al.  Finerenone and Kidney Outcomes in Patients With Heart Failure: The FINEARTS-HF Trial.  J Am Coll Cardiol  2025 Jan 21;85(2):159-168. doi:10.1016/j.jacc.2024.10.091
  28. Desai AS, Vaduganathan M, Claggett BL, Kulac IJ, Jhund PS, Cunningham J, Borentain M, Lay-Flurrie J, Viswanathan P, Rohwedder K  et al.  Finerenone in Patients With a Recent Worsening Heart Failure Event: The FINEARTS-HF Trial.  J Am Coll Cardiol  2025 Jan 21;85(2):106-116. doi:10.1016/j.jacc.2024.09.004
  29. Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B  et al.  Time to Significant Benefit of Finerenone in Patients With Heart Failure.  J Am Coll Cardiol  2025 Jan 21;85(2):199-202. doi:10.1016/j.jacc.2024.09.018
  30. Davies MJ, van der Meer P, Verma S, Patel S, Chinnakondepalli KM, Borlaug BA, Butler J, Kitzman DW, Shah SJ, Harring S  et al.  Semaglutide in obesity-related heart failure with preserved ejection fraction and type 2 diabetes across baseline HbA1c levels (STEP-HFpEF DM): a prespecified analysis of heart failure and metabolic outcomes from a randomised, placebo-controlled trial.  Lancet Diabetes Endocrinol  2025 Jan 20;. pii:S2213-8587(24)00304-8
  31. Vaduganathan M, Claggett BL, Kulac IJ, Miao ZM, Desai AS, Jhund PS, Henderson AD, Brinker M, Lay-Flurrie J, Viswanathan P  et al.  Effects of the Nonsteroidal MRA Finerenone With and Without Concomitant SGLT2 Inhibitor Use in Heart Failure.  Circulation  2025 Jan 14;151(2):149-158. doi:10.1161/CIRCULATIONAHA.124.072055
  32. Lei Y, Li Z, Bui Q, DePaul O, Nicol GE, Mohr DC, Fong MWM, Metts CL, Lee SI, Tomazin SE  et al.  Satisfaction, user experiences, and initial efficacy of a technology-supported self-management intervention (iSMART) to improve post-stroke functioning: a remoted randomized controlled trial.  Top Stroke Rehabil  2025 Jan 10;:1-15. doi:10.1080/10749357.2025.2450950
  33. Wang X, Li Y, Lin Z, Pla I, Gajjela R, Mattamana BB, Joshi M, Liu Y, Wang H, Zun AB  et al.  Micropillar-induced changes in cell nucleus morphology enhance bone regeneration by modulating the secretome.  Res Sq  2025 Jan 07;. pii:rs.3.rs-5530535
  34. Naved BA, Han S, Koss KM, Kando MJ, Wang JJ, Weiss C, Passman MG, Wertheim JA, Luo Y, Zhang ZJ  Multivariate description of gait changes in a mouse model of peripheral nerve injury and trauma.  PLoS One  2025;20(1):e0312415. pii:e0312415
  35. Docherty KF, Henderson AD, Jhund PS, Claggett BL, Desai AS, Mueller K, Viswanathan P, Scalise A, Lam CSP, Senni M  et al.  Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial.  Circulation  2025 Jan 07;151(1):45-58. doi:10.1161/CIRCULATIONAHA.124.072011
  36. Liebovitz DM  Navigating Uncertainty in Digital Health Education.  JAMA Netw Open  2025 Jan 02;8(1):e2453095. doi:10.1001/jamanetworkopen.2024.53095
  37. Swaroop A, Yue F  Chromatin hubs drive key regulatory networks in leukemia.  Mol Cell  2025 Jan 02;85(1):1-2. doi:10.1016/j.molcel.2024.12.011
  38. Stiles-Shields C, Reyes KM, Lakhtakia T, Smith SR, Barnas OE, Gray EL, Krause CJ, Kruzan KP, Kwasny MJ, Mir Z  et al.  Correction: A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial.  BMC Psychiatry  2025 Jan 02;25(1):4. pii:4
  39. Idnay B, Xu Z, Adams WG, Adibuzzaman M, Anderson NR, Bahroos N, Bell DS, Bumgardner C, Campion T, Castro M  et al.  Environment scan of generative AI infrastructure for clinical and translational science.  Npj Health Syst  2025;2(1):4. pii:4
  40. Ragon B, Seymour A, Whipple EC, Surkis A, Haberstroh A, Muilenburg J, Rethlefsen ML, Aspinall EE, Deaver J, Dexter N  et al.  The role of information science within the clinical translational science ecosystem.  J Clin Transl Sci  2025;8(1):e224. pii:e224
  41. Vardeny O, Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F  et al.  Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.  JAMA Cardiol  2025 Jan 01;10(1):42-48. pii:e244539
  42. Nargesi AA, Adejumo P, Dhingra LS, Rosand B, Hengartner A, Coppi A, Benigeri S, Sen S, Ahmad T, Nadkarni GN  et al.  Automated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing.  JACC Heart Fail  2025 Jan;13(1):75-87. doi:10.1016/j.jchf.2024.08.012
  43. Sadeghpour A, Jiang Z, Hummel YM, Frost M, Lam CSP, Shah SJ, Lund LH, Stone GW, Swaminathan M, Weissman NJ  et al.  An Automated Machine Learning-Based Quantitative Multiparametric Approach for Mitral Regurgitation Severity Grading.  JACC Cardiovasc Imaging  2025 Jan;18(1):1-12. doi:10.1016/j.jcmg.2024.06.011
  44. Shimbo D, Shah RU, Abdalla M, Agarwal R, Ahmad FS, Anaya G, Attia ZI, Bull S, Chang AR, Commodore-Mensah Y  et al.  Transforming Hypertension Diagnosis and Management in The Era of Artificial Intelligence: A 2023 National Heart, Lung, and Blood Institute (NHLBI) Workshop Report.  Hypertension  2025 Jan;82(1):36-45. doi:10.1161/HYPERTENSIONAHA.124.22095
  45. Naved BA, Luo Y  Contrasting rule and machine learning based digital self triage systems in the USA.  NPJ Digit Med  2024 Dec 27;7(1):381. pii:381
  46. Gould A, Luan Y, Hou Y, Korobova FV, Chen L, Arrieta VA, Amidei C, Ward R, Gomez C, Castro B  et al.  Endothelial Response to Blood-Brain Barrier Disruption in the Human Brain.  JCI Insight  2024 Dec 26;. pii:e187328
  47. Ambrosy AP, Sauer AJ, Patel S, Windsor SL, Borlaug BA, Husain M, Inzucchi SE, Kitzman DW, McGuire DK, Shah SJ  et al.  Baseline kidney function and the effects of dapagliflozin on health status in heart failure in DEFINE-HF and PRESERVED-HF.  ESC Heart Fail  2024 Dec 24;. doi:10.1002/ehf2.15184
  48. Seyithanoglu D, Durak G, Keles E, Medetalibeyoglu A, Hong Z, Zhang Z, Taktak YB, Cebeci T, Tiwari P, Velichko YS  et al.  Advances for Managing Pancreatic Cystic Lesions: Integrating Imaging and AI Innovations.  Cancers (Basel)  2024 Dec 22;16(24). pii:4268
  49. Luo Y, Fraser L, Jezykowski J, Gupta NA, Miethke AG, Taylor SA, Alonso EM, Horslen S, Kohli R, Molleston JP  et al.  Interleukin 8-CXCR2-mediated neutrophil extracellular trap formation in biliary atresia associated with neutrophil extracellular trap-induced stellate cell activation.  Hepatology  2024 Dec 18;. doi:10.1097/HEP.0000000000001195
  50. Zamani P, Shah SJ, Cohen JB, Zhao M, Yang W, Afable JL, Caturla M, Maynard H, Pourmussa B, Demastus C  et al.  Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.  JAMA Cardiol  2024 Dec 18;. doi:10.1001/jamacardio.2024.4417