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Northwestern University Feinberg School of Medicine
Institute for Artificial Intelligence in Medicine

Publications

Browse the list below to see the latest scientific publications stemming from our institute faculty’s work. To view publications of specific AI faculty, please visit Membership and select a profile link.

  1. Ostrominski JW, Højbjerg Lassen MC, Claggett BL, Miao ZM, Inzucchi SE, Docherty KF, Desai AS, Jhund PS, Køber L, Ponikowski P  et al.  Sodium-glucose co-transporter 2 inhibitors and new-onset diabetes in cardiovascular or kidney disease.  Eur Heart J  2024 Nov 21;. pii:ehae780
  2. Stiles-Shields C, Reyes KM, Lakhtakia T, Smith SR, Barnas OE, Gray EL, Krause CJ, Kruzan KP, Kwasny MJ, Mir Z  et al.  A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial.  BMC Psychiatry  2024 Nov 19;24(1):828. pii:828
  3. Cai W, Liu X, Barajas S, Xiao S, Vemula S, Chen H, Yang Y, Bochers C, Henley D, Liu S  et al.  Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes.  Leukemia  2024 Nov 19;. doi:10.1038/s41375-024-02462-w
  4. Simon G, Moise N, Mohr DC  Management of Depression-Reply.  JAMA  2024 Nov 19;332(19):1674-1675. doi:10.1001/jama.2024.18405
  5. Vardeny O, Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F  et al.  Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction.  JAMA Cardiol  2024 Nov 17;. pii:e244539
  6. Selvaraj S, Patel S, Sauer AJ, McGarrah RW, Jones P, Kwee LC, Windsor SL, Ilkayeva O, Muehlbauer MJ, Newgard CB  et al.  Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction.  Circ Heart Fail  2024 Nov;17(11):e011980. doi:10.1161/CIRCHEARTFAILURE.124.011980
  7. Chimura M, Petrie MC, Schou M, Martinez FA, Henderson AD, Claggett BL, Desai AS, Kolkhof P, Viswanathan P, Lage A  et al.  Finerenone Improves Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction Irrespective of Age: A Prespecified Analysis of FINEARTS-HF.  Circ Heart Fail  2024 Nov;17(11):e012437. doi:10.1161/CIRCHEARTFAILURE.124.012437
  8. Wu Y, Iorga M, Badhe S, Zhang J, Cantrell DR, Tanhehco EJ, Szrama N, Naidech AM, Drakopoulos M, Hasan ST  et al.  Precise Image-level Localization of Intracranial Hemorrhage on Head CT Scans with Deep Learning Models Trained on Study-level Labels.  Radiol Artif Intell  2024 Nov;6(6):e230296. doi:10.1148/ryai.230296
  9. Kim M, Wang X, Li Y, Lin Z, Collins CP, Liu Y, Ahn Y, Tsal HM, Song JW, Duan C  et al.  Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration.  Bioact Mater  2024 Nov;41:427-439. doi:10.1016/j.bioactmat.2024.07.029
  10. Doiron JE, Xia H, Yu X, Nevins AR, LaPenna KB, Sharp TE, Goodchild TT, Allerton TD, Elgazzaz M, Lazartigues E  et al.  Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.  Br J Pharmacol  2024 Nov;181(21):4294-4310. doi:10.1111/bph.16493
  11. Hasjim BJ, Harris A, Balbale SN, Obayemi JE, Beestrum M, Polineni P, Paukner M, Mohammadi M, Dentici OC, Kershaw KN  et al.  Social Disadvantage and Disparities in Chronic Liver Disease: A Systematic Review.  Am J Gastroenterol  2024 Oct 30;. doi:10.14309/ajg.0000000000003171
  12. Vaduganathan M, Filippatos G, Claggett BL, Desai AS, Jhund PS, Henderson A, Brinker M, Kolkhof P, Schloemer P, Lay-Flurrie J  et al.  Author Correction: Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes.  Nat Med  2024 Oct 28;. doi:10.1038/s41591-024-03372-1
  13. , Dekker J, Oksuz BA, Zhang Y, Wang Y, Minsk MK, Kuang S, Yang L, Gibcus JH, Krietenstein N  et al.  An integrated view of the structure and function of the human 4D nucleome.  bioRxiv  2024 Oct 27;. pii:2024.09.17.613111
  14. Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M  et al.  Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.  N Engl J Med  2024 Oct 24;391(16):1475-1485. doi:10.1056/NEJMoa2407107
  15. Mc Causland FR, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, Henderson AD, Brinker M, Perkins R, Scheerer MF  et al.  Finerenone and Kidney Outcomes in Patients with Heart Failure: The FINEARTS-HF Trial.  J Am Coll Cardiol  2024 Oct 22;. pii:S0735-1097(24)10252-5
  16. Solomon SD, Ostrominski JW, Wang X, Shah SJ, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Verma S, Abildstrøm SZ  et al.  Effect of Semaglutide on Cardiac Structure and Function in Patients With Obesity-Related Heart Failure.  J Am Coll Cardiol  2024 Oct 22;84(17):1587-1602. doi:10.1016/j.jacc.2024.08.021
  17. Verma S, Butler J, Borlaug BA, Davies MJ, Kitzman DW, Petrie MC, Shah SJ, Jensen TJ, Rasmussen S, Rönnbäck C  et al.  Atrial Fibrillation and Semaglutide Effects in Obesity-Related Heart Failure With Preserved Ejection Fraction: STEP-HFpEF Program.  J Am Coll Cardiol  2024 Oct 22;84(17):1603-1614. doi:10.1016/j.jacc.2024.08.023
  18. Verma S, Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Rönnbäck C, Abildstrøm SZ, Liisberg K  et al.  Inflammation in Obesity-Related HFpEF: The STEP-HFpEF Program.  J Am Coll Cardiol  2024 Oct 22;84(17):1646-1662. doi:10.1016/j.jacc.2024.08.028
  19. Hasjim BJ, Mohammadi M, Balbale SN, Paukner M, Banea T, Shi H, Furmanchuk A, VanWagner LB, Zhao L, Duarte-Rojo A  et al.  High hospitalization rates and risk factors among frail patients with cirrhosis: A 10-year population-based cohort study.  Clin Gastroenterol Hepatol  2024 Oct 17;. pii:S1542-3565(24)00903-0
  20. Nargesi AA, Adejumo P, Dhingra LS, Rosand B, Hengartner A, Coppi A, Benigeri S, Sen S, Ahmad T, Nadkarni GN  et al.  Automated Identification of Heart Failure With Reduced Ejection Fraction Using Deep Learning-Based Natural Language Processing.  JACC Heart Fail  2024 Oct 09;. pii:S2213-1779(24)00618-8
  21. Ozyoruk KB, Harmon SA, Lay NS, Yilmaz EC, Bagci U, Citrin DE, Wood BJ, Pinto PA, Choyke PL, Turkbey B  AI-ADC: Channel and Spatial Attention-Based Contrastive Learning to Generate ADC Maps from T2W MRI for Prostate Cancer Detection.  J Pers Med  2024 Oct 09;14(10). pii:1047
  22. Goldstein JA, Nateghi R, Cooper LAD  Machine Learning Assessment of Gestational Age in Accelerated Maturation, Delayed Maturation, Villous Edema, Chorangiosis, and Intrauterine Fetal Demise.  Arch Pathol Lab Med  2024 Oct 07;. doi:10.5858/arpa.2024-0274-OA
  23. Fudim M, Borlaug BA, Mohan RC, Price MJ, Fail P, Goyal P, Hummel SL, Zirakashvili T, Shaburishvili T, Patel RB  et al.  Endovascular Ablation of the Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: The REBALANCE-HF Randomized Clinical Trial.  JAMA Cardiol  2024 Oct 02;. pii:e242612
  24. Zhou T, Zhang B, Zhang D, Wu Q, Chen J, Li L, Lu Y, Becich MJ, Blecker S, Chilukuri N  et al.  Body Mass Index and Postacute Sequelae of SARS-CoV-2 Infection in Children and Young Adults.  JAMA Netw Open  2024 Oct 01;7(10):e2441970. doi:10.1001/jamanetworkopen.2024.41970
  25. Haynes G, Muhammad F, Weber KA, Khan AF, Hameed S, Shakir H, Van Hal M, Dickson D, Rohan M, Dhaher Y  et al.  Tract-specific magnetization transfer ratio provides insights into the severity of degenerative cervical myelopathy.  Spinal Cord  2024 Oct 01;. doi:10.1038/s41393-024-01036-y
  26. Dey S, Kurbanzade AK, Gel ES, Mihaljevic J, Mehrotra S  Optimization Modeling for Pandemic Vaccine Supply Chain Management: A Review and Future Research Opportunities.  Nav Res Logist  2024 Oct;71(7):976-1016. doi:10.1002/nav.22181
  27. Chaudhury AS, Ige M, Marwah S, Zhou X, Andrews CA, Kanwar K, Evans CT, Kho AN, Stein JD, Bryar PJ  et al.  Race, Social Determinants of Health, and the Quality of Diabetic Eye Care.  JAMA Ophthalmol  2024 Oct 01;142(10):961-970. doi:10.1001/jamaophthalmol.2024.3528
  28. Docherty KF, Buendia Lopez R, Folkvaljon F, de Boer RA, Cowie MR, Hammarstedt A, Kitzman DW, Kosiborod MN, Langkilde AM, Reicher B  et al.  Effect of Dapagliflozin on Accelerometer-Based Measures of Physical Activity in Patients With Heart Failure: An Analysis of the DETERMINE Trials.  Circ Heart Fail  2024 Oct;17(10):e012349. doi:10.1161/CIRCHEARTFAILURE.124.012349
  29. Kitzman DW, Voors AA, Mentz RJ, Lewis GD, Perl S, Myte R, Kaguthi G, Sjöström CD, Källgren C, Shah SJ  Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection Fraction: The AMETHYST Randomized Clinical Trial.  JAMA Cardiol  2024 Oct 01;9(10):892-900. doi:10.1001/jamacardio.2024.2435
  30. Shah SJ, Rigolli M, Javidialsaadi A, Patel RB, Khadra S, Goyal P, Little S, Wever-Pinzon O, Owens AT, Skali H  et al.  Cardiac Myosin Inhibition in Heart Failure With Normal and Supranormal Ejection Fraction: Primary Results of the EMBARK-HFpEF Trial.  JAMA Cardiol  2024 Sep 30;. doi:10.1001/jamacardio.2024.3810
  31. Yang M, Henderson AD, Talebi A, Atherton JJ, Chiang CE, Chopra V, Comin-Colet J, Kosiborod MN, Kerr Saraiva JF, Claggett BL  et al.  Effect of Finerenone on the KCCQ in Patients With HFmrEF/HFpEF: A Prespecified Analysis of FINEARTS-HF.  J Am Coll Cardiol  2024 Sep 29;. pii:S0735-1097(24)08532-2
  32. Docherty KF, Henderson AD, Jhund PS, Claggett BL, Desai AS, Mueller K, Viswanathan P, Scalise A, Lam CSP, Senni M  et al.  Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure with Mildly Reduced and Preserved Ejection Fraction: a Prespecified Analysis of The FINEARTS-HF Trial.  Circulation  2024 Sep 29;. doi:10.1161/CIRCULATIONAHA.124.072011
  33. Adekkanattu P, Furmanchuk A, Wu Y, Pathak A, Patra BG, Bost S, Morrow D, Wang GH, Yang Y, Forrest NJ  et al.  Deep learning for identifying personal and family history of suicidal thoughts and behaviors from EHRs.  NPJ Digit Med  2024 Sep 28;7(1):260. pii:260
  34. Vaduganathan M, Claggett BL, Kulac IJ, Miao ZM, Desai AS, Jhund PS, Henderson AD, Brinker M, Lay-Flurrie J, Viswanathan P  et al.  Effects of the Non-Steroidal MRA Finerenone with and without Concomitant SGLT2 Inhibitor Use in Heart Failure.  Circulation  2024 Sep 28;. doi:10.1161/CIRCULATIONAHA.124.072055
  35. Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B  et al.  Estimated Long-Term Benefits of Finerenone in Heart Failure: A Prespecified Secondary Analysis of the FINEARTS-HF Randomized Clinical Trial.  JAMA Cardiol  2024 Sep 27;. doi:10.1001/jamacardio.2024.3782
  36. Vaduganathan M, Claggett BL, Desai AS, Jhund PS, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B  et al.  Time to Significant Benefit of Finerenone in Patients With Heart Failure.  J Am Coll Cardiol  2024 Sep 26;. pii:S0735-1097(24)08512-7
  37. Desai AS, Vaduganathan M, Claggett BL, Kulac IJ, Jhund PS, Cunningham J, Borentain M, Lay-Flurrie J, Viswanathan P, Rohwedder K  et al.  Finerenone in Patients With a Recent Worsening Heart Failure Event: The FINEARTS-HF Trial.  J Am Coll Cardiol  2024 Sep 25;. pii:S0735-1097(24)08452-3
  38. Robinson A, Flom M, Forman-Hoffman VL, Histon T, Levy M, Darcy A, Ajayi T, Mohr DC, Wicks P, Greene C  et al.  Equity in Digital Mental Health Interventions in the United States: Where to Next?  J Med Internet Res  2024 Sep 24;26:e59939. pii:e59939
  39. Xian S, Grabowska ME, Kullo IJ, Luo Y, Smoller JW, Wei WQ, Jarvik G, Mooney S, Crosslin D  Language-model-based patient embedding using electronic health records facilitates phenotyping, disease forecasting, and progression analysis.  Res Sq  2024 Sep 23;. pii:rs.3.rs-4708839
  40. Jhund PS, Talebi A, Henderson AD, Claggett BL, Vaduganathan M, Desai AS, Lam CSP, Pitt B, Senni M, Shah SJ  et al.  Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis.  Lancet  2024 Sep 21;404(10458):1119-1131. doi:10.1016/S0140-6736(24)01733-1
  41. Pabon MA, Vaduganathan M, Claggett BL, Chatur S, Siqueira S, Marti-Castellote P, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN  et al.  In-hospital course of patients with heart failure with improved ejection fraction in the DELIVER trial.  Eur J Heart Fail  2024 Sep 19;. doi:10.1002/ejhf.3410
  42. Perry AS, Amancherla K, Huang X, Lance ML, Farber-Eger E, Gajjar P, Amrute J, Stolze L, Zhao S, Sheng Q  et al.  Clinical-transcriptional prioritization of the circulating proteome in human heart failure.  Cell Rep Med  2024 Sep 17;5(9):101704. pii:101704
  43. Shah SJ, Sharma K, Borlaug BA, Butler J, Davies M, Kitzman DW, Petrie MC, Verma S, Patel S, Chinnakondepalli KM  et al.  Semaglutide and diuretic use in obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF-DM trials.  Eur Heart J  2024 Sep 14;45(35):3254-3269. doi:10.1093/eurheartj/ehae322
  44. Peterson TE, Lima JAC, Shah SJ, Bluemke DA, Bertoni AG, Liu Y, Ngo D, Varadarajan V, Mychaleckyj JC, Johnson CW  et al.  Proteomics of left ventricular structure in the Multi-Ethnic Study of Atherosclerosis.  ESC Heart Fail  2024 Sep 12;. doi:10.1002/ehf2.15073
  45. Guare LA, Humphrey LA, Rush M, Pollie M, Jaworski J, Akerele AT, Luo Y, Weng C, We WQ, Kottyan L  et al.  Enhancing genetic association power in endometriosis through unsupervised clustering of clinical subtypes identified from electronic health records.  Res Sq  2024 Sep 09;. pii:rs.3.rs-5004325
  46. Kosiborod MN, Deanfield J, Pratley R, Borlaug BA, Butler J, Davies MJ, Emerson SS, Kahn SE, Kitzman DW, Lingvay I  et al.  Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials.  Lancet  2024 Sep 07;404(10456):949-961. doi:10.1016/S0140-6736(24)01643-X
  47. Culler KL, Sinha A, Filipp M, Giro P, Allen NB, Taylor KD, Guo X, Thorp E, Freed BH, Greenland P  et al.  Metabolomic profiling identifies novel metabolites associated with cardiac dysfunction.  Sci Rep  2024 Sep 05;14(1):20694. pii:20694
  48. Rojas JC, Lyons PG, Chhikara K, Chaudhari V, Bhavani SV, Nour M, Buell KG, Smith KD, Gao CA, Amagai S  et al.  A Common Longitudinal Intensive Care Unit data Format (CLIF) to enable multi-institutional federated critical illness research.  medRxiv  2024 Sep 04;. pii:2024.09.04.24313058
  49. Giro P, Filipp M, Zhang MJ, Moser ED, Thorp EB, Dalal PJ, Shah RV, Ellinor PT, Cunningham JW, Jurgens SJ  et al.  Proteomic Profile of the ICAM1 p.K56M HFpEF Risk Variant.  JACC Basic Transl Sci  2024 Sep;9(9):1073-1084. doi:10.1016/j.jacbts.2024.05.016
  50. Vaduganathan M, Filippatos G, Claggett BL, Desai AS, Jhund PS, Henderson A, Brinker M, Kolkhof P, Schloemer P, Lay-Flurrie J  et al.  Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes.  Nat Med  2024 Sep 01;. doi:10.1038/s41591-024-03264-4